التفاصيل البيبلوغرافية
| العنوان: |
Table_1_Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference.docx |
| المؤلفون: |
Yuna Miyajima, Shigehiro Karashima, Kazuhiro Ogai, Kouki Taniguchi, Kohei Ogura, Masaki Kawakami, Hidetaka Nambo, Mitsuhiro Kometani, Daisuke Aono, Masashi Demura, Takashi Yoneda, Hiromasa Tsujiguchi, Akinori Hara, Hiroyuki Nakamura, Shigefumi Okamoto |
| سنة النشر: |
2022 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Clinical Microbiology, Medical Bacteriology, Medical Infection Agents (incl. Prions), Medical Virology, gut microbiome, sex, dyslipidemia, causal inference, linear non-gaussian acyclic model |
| الوصف: |
Dyslipidemia (DL) is one of the most common lifestyle-related diseases. There are few reports showing the causal relationship between gut microbiota (GM) and DL. In the present study, we used a linear non-Gaussian acyclic model (LiNGAM) to evaluate the causal relationship between GM and DL. A total of 79 men and 82 women aged 40 years or older living in Shika-machi, Ishikawa Prefecture, Japan were included in the analysis, and their clinical information was investigated. DNA extracted from the GM was processed to sequence the 16S rRNA gene using next-generation sequencing. Participants were divided into four groups based on sex and lipid profile information. The results of one-way analysis of covariance, linear discriminant analysis effect size, and least absolute value reduction and selection operator logistic regression model indicated that several bacteria between men and women may be associated with DL. The LiNGAM showed a presumed causal relationship between different bacteria and lipid profiles in men and women. In men, Prevotella 9 and Bacteroides were shown to be potentially associated with changes in low- and high-density lipoprotein cholesterol levels. In women, the LiNGAM results showed two bacteria, Akkermansia and Escherichia/Shigella, had a presumptive causal relationship with lipid profiles. These results may provide a new sex-based strategy to reduce the risk of developing DL and to treat DL through the regulation of the intestinal environment using specific GM. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/Table_1_Impact_of_gut_microbiome_on_dyslipidemia_in_japanese_adults_Assessment_of_the_Shika-machi_super_preventive_health_examination_results_for_causal_inference_docx/20786689Test |
| DOI: |
10.3389/fcimb.2022.908997.s001 |
| الإتاحة: |
https://doi.org/10.3389/fcimb.2022.908997.s001Test
https://figshare.com/articles/dataset/Table_1_Impact_of_gut_microbiome_on_dyslipidemia_in_japanese_adults_Assessment_of_the_Shika-machi_super_preventive_health_examination_results_for_causal_inference_docx/20786689Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.C5A370CC |
| قاعدة البيانات: |
BASE |
