التفاصيل البيبلوغرافية
| العنوان: |
Gender-specific relationship between thigh muscle and fat mass and brain amyloid-β positivity |
| المؤلفون: |
Kang, Sung Hoon, Lee, Kyung Hyun, Chang, Yoosoo, Choe, Yeong Sim, Kim, Jun Pyo, Jang, Hyemin, Shin, Hee Young, Kim, Hee Jin, Koh, Seong-Beom, Na, Duk L., Seo, Sang Won, Kang, Mira |
| المصدر: |
Alzheimer's Research & Therapy ; volume 14, issue 1 ; ISSN 1758-9193 |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Cognitive Neuroscience, Neurology (clinical), Neurology |
| الوصف: |
Background The relationship of specific body composition in the thighs and brain amyloid-beta (Aβ) deposition remained unclear, although there were growing evidence that higher muscle and fat mass in thighs had a protective effect against cardiometabolic syndromes. To determine whether muscle mass and fat mass in the thighs affected amyloid-beta (Aβ) positivity differently in relation to gender, we investigated the association of muscle mass and fat mass with Aβ positivity using positron emission tomography (PET) in individuals without dementia. Methods We recruited 240 participants (134 [55.8%] males, 106 [44.2%] females) without dementia ≥45 years of age who underwent Aβ PET, bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DEXA) scans of the hip in the health promotion center at Samsung Medical Center in Seoul, Korea. Lower extremity skeletal muscle mass index (LASMI) was measured using BIA, and gluteofemoral fat percentage (GFFP) was estimated using DEXA scans of the hip. We investigated the associations of LASMI and GFFP with Aβ positivity using logistic regression analyses after controlling for age, APOE4 genotype, and cognitive stage. Results Higher muscle mass in the thighs, measured as LASMI (odds ratio [OR]=0.27, 95% confidence interval [CI] 0.08 to 0.84, p =0.031) was associated with a lesser risk of Aβ positivity in only females. Higher fat mass in the thighs, measured as GFFP (OR=0.84, 95% CI 0.73 to 0.95, p =0.008) was associated with a lesser risk of Aβ positivity in only males. However, the association between LAMSI ( p for interaction = 0.810), GFFP ( p for interaction = 0.075) and Aβ positivity did not significantly differ by gender. Furthermore, LAMSI only negatively correlated with centiloid (CL) values in females ( r =−0.205, p =0.037), and GFFP only negatively correlated with CL values only in males ( r =−0.253, p =0.004). Conclusions Our findings highlight the importance of recognizing that gender differences exist with respect to the specific body ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1186/s13195-022-01086-5 |
| DOI: |
10.1186/s13195-022-01086-5.pdf |
| DOI: |
10.1186/s13195-022-01086-5/fulltext.html |
| الإتاحة: |
https://doi.org/10.1186/s13195-022-01086-5Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.C585D70E |
| قاعدة البيانات: |
BASE |
