دورية أكاديمية
Durability of blood pressure reduction after ultrasound renal denervation: three-year follow-up of the treatment arm of the randomised RADIANCE-HTN SOLO trial
| العنوان: | Durability of blood pressure reduction after ultrasound renal denervation: three-year follow-up of the treatment arm of the randomised RADIANCE-HTN SOLO trial |
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| المؤلفون: | Rader, Florian, Kirtane, Ajay Kirtane, Wang, Yale, Daemen, Joost, Lurz, Philipp, Sayer, Jeremy, Saxena, Manish, Levy, Terry, Scicli, Andrea Scicli, Thackeray, Lisa, Azizi, Michel, Weber, Michael Weber |
| المساهمون: | Cedars-Sinai Medical Center, Abbott Northwestern Hospital, Erasmus University Medical Center Rotterdam (Erasmus MC), Leipzig University / Universität Leipzig, Queen Mary University of London (QMUL), Royal Bournemouth Hospital, CIC - HEGP (CIC 1418), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou APHP (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Européen Georges Pompidou APHP (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), CArdiovasculaire Rénal Transplantation nEurovasculaire Paris (DMU CARTE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO) |
| المصدر: | ISSN: 1774-024X ; EuroIntervention ; https://hal.science/hal-04052095Test ; EuroIntervention , 2022, 18 (8), pp.e677-e685. ⟨10.4244/EIJ-D-22-00305⟩. |
| بيانات النشر: | HAL CCSD EuroPCR |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | clinical research clinical trials renal sympathetic denervation ultrasound renal denervation, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Background: While the blood pressure (BP)-lowering effect of renal denervation (RDN) has been established, long-term durability is a key prerequisite for a broader clinical implementation. Aims: Our aims were to assess the long-term durability of the office BP (OBP)-lowering efficacy, antihypertensive medication (AHM) use, and safety of ultrasound RDN (uRDN). Methods: Four weeks after withdrawal of AHM, patients with untreated daytime ambulatory BP ≥135/85 mmHg and <170/105 mmHg were randomised to uRDN (n=74) or sham (n=72) in the RADIANCE-HTN SOLO trial. Initiation of AHM was encouraged for home BP >135/85 mmHg following primary endpoint ascertainment at 2 months. Patients and physicians were unblinded at 6 months. Results: Fifty-one of 74 patients (age: 53.9±11 years; 67% men) originally randomised to uRDN completed the 36-month follow-up. Initial screening OBP upon study entry was 145/92±14/10 mmHg on a mean of 1.2 AHM (range: 0-2.0). Baseline OBP after AHM washout was 154/99±13/8 mmHg. At 36 months, patients were on an average of 1.3 AHM (range:0-3.0) with 8 patients on no AHM. OBP decreased by-18/-11±15/9 mmHg from baseline to 36 months (p<0.001 for both). Overall, OBP control (<140/90 mmHg) improved from 29.4% at screening to 45.1% at 36 months (p=0.059). For patients uncontrolled at screening (n=36), systolic OBP decreased by-10.8 mmHg (p<0.001) at 36 months on similar AHM (p=0.158). Conclusions: The safety and effectiveness of uRDN was durable to 36 months, with reduced OBP and improved OBP control despite a similar starting medication burden. No new uRDN-related long-term safety concerns were identified. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04052095; https://hal.science/hal-04052095Test; https://hal.science/hal-04052095/documentTest; https://hal.science/hal-04052095/file/2022-Rader-Euro%20Intervention.pdfTest |
| DOI: | 10.4244/EIJ-D-22-00305 |
| الإتاحة: | https://doi.org/10.4244/EIJ-D-22-00305Test https://hal.science/hal-04052095Test https://hal.science/hal-04052095/documentTest https://hal.science/hal-04052095/file/2022-Rader-Euro%20Intervention.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.C581F652 |
| قاعدة البيانات: | BASE |
| DOI: | 10.4244/EIJ-D-22-00305 |
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