دورية أكاديمية
Guillain-Barré syndrome as clinical presentation of a recently acquired hepatitis C
| العنوان: | Guillain-Barré syndrome as clinical presentation of a recently acquired hepatitis C |
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| المؤلفون: | Boccia F., Florio L. L., Durante-Mangoni E., Zampino R. |
| المساهمون: | Boccia, F., Florio, L. L., Durante-Mangoni, E., Zampino, R. |
| سنة النشر: | 2023 |
| المجموعة: | Università degli Studi della Campania "Luigi Vanvitelli": CINECA IRIS V: |
| مصطلحات موضوعية: | Diagnosi, Paralysi, Post-viral syndrome, Serology, Viremia |
| الوصف: | About 40% of the Guillain-Barré syndrome (GBS)cases are associated with prodromal infections; occasionally, it has been associated to chronic hepatitis C or its reactivation. A 38-year-old man came to our attention after transaminase elevation occurred during recovery from GBS. All the possible causes of acute hepatitis were excluded except forthe positivity of HCVRNA, and a diagnosis of new onset hepatitis C was made. Recalling patient history, we observed that (i) anti-HCV antibodies were negative and liver enzymes were normal 7weeks before GBS onset; (ii) in the early stages of ICU admission, liver enzymes started to rise, but the elevation remained mild under steroid treatment; (iii) serum aminotransferase peak occurred 11weeks after GBS onset; and (iv) HCV RNA was already significantly high when anti-HCV antibodies became positive, consistent with an acute hepatitis. Furthermore, anti-HCV seroconversion was likely delayed or blurred by steroids and immunoglobulin infusions. The interval of time between GBS onset and transaminase elevation compared with the patient clinical history allows us to establish a cause-effect relationship between the two diseases. All patients with GBS should be tested for hepatitis C, or its reactivation if already present, and followed up for an early diagnosis and treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37646952; info:eu-repo/semantics/altIdentifier/wos/WOS:001062044400001; volume:29; issue:5; firstpage:640; lastpage:643; numberofpages:4; journal:JOURNAL OF NEUROVIROLOGY; https://hdl.handle.net/11591/514630Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85169165294 |
| DOI: | 10.1007/s13365-023-01167-7 |
| الإتاحة: | https://doi.org/10.1007/s13365-023-01167-7Test https://hdl.handle.net/11591/514630Test |
| رقم الانضمام: | edsbas.C57E5D1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s13365-023-01167-7 |
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