دورية أكاديمية
Effects of trifluoperazine on rat prolactin, growth hormone, thyroid stimulating hormone and adrenocorticotrophin secretion in vitro
| العنوان: | Effects of trifluoperazine on rat prolactin, growth hormone, thyroid stimulating hormone and adrenocorticotrophin secretion in vitro |
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| المؤلفون: | Powell, Ruth C., Daniels, Mark, Innes, Graham K., Ashby, Michael J., Mashiter, Keith |
| المصدر: | Acta Endocrinologica ; volume 103, issue 4, page 492-496 ; ISSN 0804-4643 1479-683X |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 1983 |
| مصطلحات موضوعية: | Endocrinology, General Medicine, Endocrinology, Diabetes and Metabolism |
| الوصف: | We have studied the effects of trifluoperazine, a proposed inhibitor of calmodulin directed cellular function, on adrenocorticotrophic hormone (ACTH), thyroid stimulating hormone (TSH), prolactin (Prl) and growth hormone (GH) secretion from primary cultures of rat adenohypophyseal cells. 5 × 10 −6 m and 10 −5 m trifluoperazine caused a significant ( P < 0.005) reversible dose-related decrease in basal Prl secretion but was less effective on basal GH secretion, significant reversible inhibition ( P < 0.005) occurring only with 10 −5 m . Trifluoperazine did not consistently alter basal ACTH or TSH secretion but did inhibit 10 −2 m theophylline stimulation of ACTH, Prl and GH secretion and 1.5 × 10 −7 m TRH stimulation of TSH and Prl secretion. Paradoxically 10 −5 m trifluoperazine enhanced theophylline stimulation of TSH secretion. Our results show trifluoperazine to have differential effects on Prl, GH, ACTH and TSH secretion, which are consistent with the known calcium dependence of pituitary hormone secretion and may suggest a role for calmodulin in this process. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.1530/acta.0.1030492 |
| الإتاحة: | https://doi.org/10.1530/acta.0.1030492Test https://eje.bioscientifica.com/view/journals/eje/103/4/acta_103_4_011.xmlTest |
| رقم الانضمام: | edsbas.C54EDEDF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1530/acta.0.1030492 |
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