دورية أكاديمية
Long-Term Mortality of Patients with an Alcohol-Related Wernicke–Korsakoff Syndrome
| العنوان: | Long-Term Mortality of Patients with an Alcohol-Related Wernicke–Korsakoff Syndrome |
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| المؤلفون: | Sanvisens, Arantza, Zuluaga, Paola, Fuster, Daniel, Rivas, Inmaculada, Tor, Jordi, Marcos, Miguel, Chamorro, Antonio J., Muga, Roberto |
| المساهمون: | Ministry of Economy and Competitiveness, Carlos III Institute of Health, Networks for Cooperative Research in Health-RETICS, European fund for regional development, Ministry of Health, Social Services and Equality, Fulbright Scholar Program - Ministry of Education |
| المصدر: | Alcohol and Alcoholism ; volume 52, issue 4, page 466-471 ; ISSN 0735-0414 1464-3502 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | General Medicine |
| الوصف: | Aims To characterize a series of contemporary patients with alcohol-related Wernicke's encephalopathy (WE) or Korsakoff's syndrome (KS) and to update the current prognosis of disease. Methods Retrospective and prospective study of patients diagnosed with an alcohol-related WE or KS between 2002 and 2011 in a tertiary hospital. Socio-demographic, alcohol use characteristics, signs and symptoms, co-morbidity and blood parameters were obtained at admission. Patients were followed up until 2013 and causes of death were ascertained through the review of charts. Results Sixty-one patients were included (51 with WE and 10 with KS). Among patients with WE, 78% were men and age at diagnosis was 57 years (interquartile range (IQR): 49–66). Twenty-three percent fulfilled the classic WE triad. Regarding Caine's criteria for WE, 70.6% presented with at least two out of four signs or symptoms. Median follow-up of patients with WE syndrome was 5.3 years (IQR: 2.6–8.8), the cumulated mortality was 45% and death rate of 7.4 × 100 person-years (95% confidence interval (CI): 4.8–10.9). Overall, 50% of patients would be expected to die within 8 years of WE episode and main causes of death included serious bacterial infections (44.5%) and cancer (33.3%). Conclusions Survival of patients with an alcohol-related Wernicke–Korsakoff syndrome is poor; pursuing treatment of alcohol use disorder and early diagnosis of thiamine deficiency is a priority for improving clinical outcomes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/alcalc/agx013 |
| الإتاحة: | https://doi.org/10.1093/alcalc/agx013Test http://academic.oup.com/alcalc/article-pdf/52/4/466/33212998/agx013.pdfTest |
| رقم الانضمام: | edsbas.C5066E17 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/alcalc/agx013 |
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