دورية أكاديمية
Beliefs and preferences regarding biological treatments for severe asthma
| العنوان: | Beliefs and preferences regarding biological treatments for severe asthma |
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| المؤلفون: | Bikov A., Oguzulgen I. K., Baiardini I., Contoli M., Emelyanov A., Fassio O., Ivancevich J. C., Kaidashev I., Kowal K., Labor M., Lahousse L., Mihaicuta S., Novakova S., Padilla Galo A., Simidchiev A., Tiotiu A., Ansotegui I. J., Bernstein J. A., Boulet L. P., Canonica G. W., Dubuske L., Rosario N., Santus P., Braido F., Ardelean C., Badellino H., Blua A., Castillo A., Carpagnano Giovanna E., Chong-Neto Herberto J., Colodenco F. D., Md Colombaro D., Correia-De-Sousa J., Di Marco F., Dobashi K., Garcia R., Gomez R. M., Gopko O., Guidos G., Hajduk M., Hermanowicz-Salamon J., Heffler E., Karadag B., Kalyoncu A. F., Keren M., Kolilekas L., Kocwin M., Krusheva B., Larenas Linnemann D., Litovchenko I., Marcipar A., Meza L. E., Nedeva D., Novakova P., Plavec D., Popovic-Grle S., Puggioni F., Pur Oziygit L., Rodrigez N., Ryan D., Ruzsics I., Scichilone N., Serpa F., Steiropoulos P., Solidoro P., Turkalj M., Umanets T., Victorio C. F., Zubeldia J. M., Yachnyk V., Zitt M. |
| المساهمون: | Bikov A., Oguzulgen I.K., Baiardini I., Contoli M., Emelyanov A., Fassio O., Ivancevich J.C., Kaidashev I., Kowal K., Labor M., Lahousse L., Mihaicuta S., Novakova S., Padilla Galo A., Simidchiev A., Tiotiu A., Ansotegui I.J., Bernstein J.A., Boulet L.P., Canonica G.W., Dubuske L., Rosario N., Santus P., Braido F., Ardelean C., Badellino H., Blua A., Castillo A., Carpagnano Giovanna E., Chong-Neto Herberto J., Colodenco F.D., Md Colombaro D., Correia-De-Sousa J., Di Marco F., Dobashi K., Garcia R., Gomez R.M., Gopko O., Guidos G., Hajduk M., Hermanowicz-Salamon J., Heffler E., Karadag B., Kalyoncu A.F., Keren M., Kolilekas L., Kocwin M., Krusheva B., Larenas Linnemann D., Litovchenko I., Marcipar A., Meza L.E., Nedeva D., Novakova P., Plavec D., Popovic-Grle S., Puggioni F., Pur Oziygit L., Rodrigez N., Ryan D., Ruzsics I., Scichilone N., Serpa F., Steiropoulos P., Solidoro P., Turkalj M., Umanets T., Victorio C.F., Zubeldia J.M., Yachnyk V., Zitt M. |
| بيانات النشر: | Elsevier Inc. |
| سنة النشر: | 2020 |
| المجموعة: | IRIS Università degli Studi di Palermo |
| مصطلحات موضوعية: | Behavior, Belief, Biological drug, Severe asthma, Settore MED/10 - Malattie Dell'Apparato Respiratorio |
| الوصف: | Background: Severe asthma is a serious condition with a significant burden on patients' morbidity, mortality, and quality of life. Some biological therapies targeting the IgE and interleukin-5 (IL5) mediated pathways are now available. Due to the lack of direct comparison studies, the choice of which medication to use varies. We aimed to explore the beliefs and practices in the use of biological therapies in severe asthma, hypothesizing that differences will occur depending on the prescribers’ specialty and experience. Methods: We conducted an online survey composed of 35 questions in English. The survey was circulated via the INterasma Scientific Network (INESNET) platform as well as through social media. Responses from allergists and pulmonologists, both those with experience of prescribing omalizumab with (OMA/IL5) and without (OMA) experience with anti-IL5 drugs, were compared. Results: Two hundred eighty-five (285) valid questionnaires from 37 countries were analyzed. Seventy-on percent (71%) of respondents prescribed biologics instead of oral glucocorticoids and believed that their side effects are inferior to those of Prednisone 5 mg daily. Agreement with ATS/ERS guidelines for identifying severe asthma patients was less than 50%. Specifically, significant differences were found comparing responses between allergists and pulmonologists (Chi-square test, p < 0.05) and between OMA/IL5 and OMA groups (p < 0.05). Conclusions: Uncertainties and inconsistencies regarding the use of biological medications have been shown. The accuracy of prescribers to correctly identify asthma severity, according to guidelines criteria, is quite poor. Although a substantial majority of prescribers believe that biological drugs are safer than low dose long-term treatment with oral steroids, and that they must be used instead of oral steroids, every effort should be made to further increase awareness. Efficacy as disease modifiers, biomarkers for selecting responsive patients, timing for outcomes evaluation, and checks need ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32774661; info:eu-repo/semantics/altIdentifier/wos/WOS:000563791200006; volume:13; issue:7; numberofpages:12; journal:THE WORLD ALLERGY ORGANIZATION JOURNAL; http://hdl.handle.net/10447/492761Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85088982108 |
| DOI: | 10.1016/j.waojou.2020.100441 |
| الإتاحة: | https://doi.org/10.1016/j.waojou.2020.100441Test http://hdl.handle.net/10447/492761Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C4C2A3B3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.waojou.2020.100441 |
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