دورية أكاديمية
The predominance of genotype 3 in Hepatitis C virus in the province of kahramanmaras, Turkey/Genotype distribution of syrian refugee patients with Hepatitis C in Kahramanmaras Province
| العنوان: | The predominance of genotype 3 in Hepatitis C virus in the province of kahramanmaras, Turkey/Genotype distribution of syrian refugee patients with Hepatitis C in Kahramanmaras Province |
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| المؤلفون: | KiriÅŸci, Ö., Çalışkan, Ahmet |
| بيانات النشر: | Kowsar Medical Publishing Company |
| سنة النشر: | 2019 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | Hepatitis C Virus, Genotype, Refugees, Turkey, virus RNA, adult, Article, DNA extraction, female, genetic analysis, hepatitis C, Hepatitis C virus genotype 1, Hepatitis C virus genotype 3, human, major clinical study, male, migration, population migration, prevalence, real time polymerase chain reaction, refugee, Syrian, virus identification |
| الوصف: | Background: The genotype determination is of importance in the clinical management of hepatitis C virus (HCV) infection. Objectives: The aim of this study was to evaluate the distribution of genotypes in HCV patients in the Kahramanmaras region, Turkey, and determine if the genotype rates of Syrian refugee patients with hepatitis C are different from the population they migrated to. Methods: Blood samples sent to the microbiology laboratory between September 2014andFebruary 2018 were examined with genotyping using a real-time PCR reagent kit. Results: The results of 274 patients who were HCV genotype-assigned were obtained from the hospital electronic information system. Of 230 Turkish HCV patients, 121 (52.8%) were identified as genotype 3, 100 (43.3%) as genotype 1, five (2.2%) as genotype 2, and four (1.7%) as genotype 4. Of the 44 Syrian refugee patients, 24 (54.5%) were identified as genotype 1, 18 (40.9%) as genotype 4, one (2.3%) as genotype 2, and one (2.3%) as genotype 3. Conclusions: Predominant genotype 3 with the prevalence of 52.8% was seen to be more frequent in the current study region than in other regions of Turkey, demonstrating the highest rate of genotype 3 infection in Turkey to date. In Syria, the predominant HCV genotype is genotype 4 with a 57% prevalence, followed by genotype 1 with 29%. In the Syrian refugees, however, the current study showed genotype 1 was more frequent than genotype 4 (54.5% vs. 40.9%). This suggests that HCV genotypes may be affected by situations such as war and migration. © 2019 Author(s). All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2008-3645 |
| العلاقة: | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/30207Test; https://doi.org/10.5812/jjm.80872Test; 12; 2-s2.0-85070191784; WOS:000466873400004 |
| DOI: | 10.5812/jjm.80872 |
| الإتاحة: | https://doi.org/10.5812/jjm.80872Test https://hdl.handle.net/11499/30207Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.C4A7B3D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20083645 |
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| DOI: | 10.5812/jjm.80872 |