دورية أكاديمية
Blinatumomab differentially modulates peripheral blood and bone marrow immune cell repertoire: A Campus ALL study
| العنوان: | Blinatumomab differentially modulates peripheral blood and bone marrow immune cell repertoire: A Campus ALL study |
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| المؤلفون: | Ocadlikova, Darina, Lussana, Federico, Fracchiolla, Nicola, Bonifacio, Massimiliano, Santoro, Lidia, Delia, Mario, Chiaretti, Sabina, Pasciolla, Crescenza, Cignetti, Alessandro, Forghieri, Fabio, Grimaldi, Francesco, Corradi, Giulia, Zannoni, Letizia, De, Propris, Stefania, Borleri, Gian Maria, Tanasi, Ilaria, Vadakekolathu, Jayakumar, Rutella, Sergio, Guarini, Anna Rita, Foà, Robin, Curti, Antonio |
| المساهمون: | D. Ocadlikova, F. Lussana, N. Fracchiolla, M. Bonifacio, L. Santoro, M. Delia, S. Chiaretti, C. Pasciolla, A. Cignetti, F. Forghieri, F. Grimaldi, G. Corradi, L. Zannoni, De, S. Propri, G.M. Borleri, I. Tanasi, J. Vadakekolathu, S. Rutella, A.R. Guarini, R. Foà, A. Curti |
| بيانات النشر: | Wiley Blackwell Publishing |
| سنة النشر: | 2023 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | acute lymphoblastic leukaemia, blinatumomab, immune cell, immune checkpoint receptor, Settore MED/15 - Malattie del Sangue |
| الوصف: | Blinatumomab is the first bi-specific T-cell engager approved for relapsed or refractory B-cell precursor acute lymphoblastic leukaemia (B-ALL). Despite remarkable clinical results, the effects of blinatumomab on the host immune cell repertoire are not fully elucidated. In the present study, we characterized the peripheral blood (PB) and, for the first time, the bone marrow (BM) immune cell repertoire upon blinatumomab treatment. Twenty-nine patients with B-ALL received blinatumomab according to clinical practice. Deep multiparametric flow cytometry was used to characterize lymphoid subsets during the first treatment cycle. Blinatumomab induced a transient redistribution of PB effector T-cell subsets and Treg cells with a persistent increase in cytotoxic NK cells, which was associated with a transient upregulation of immune checkpoint receptors on PB CD4 and CD8 T-cell subpopulations and of CD39 expression on suppressive Treg cells. Of note, BM immune T-cell subsets showed a broader post-treatment subversion, including the modulation of markers associated with a T-cell-exhausted phenotype. In conclusion, our study indicates that blinatumomab differentially modulates the PB and BM immune cell repertoire, which may have relevant clinical implications in the therapeutic setting. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37700538; info:eu-repo/semantics/altIdentifier/wos/WOS:001066170500001; volume:203; issue:4; firstpage:637; lastpage:650; numberofpages:14; journal:BRITISH JOURNAL OF HAEMATOLOGY; https://hdl.handle.net/2434/1026252Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85170702471 |
| DOI: | 10.1111/bjh.19104 |
| الإتاحة: | https://doi.org/10.1111/bjh.19104Test https://hdl.handle.net/2434/1026252Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C45C169C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/bjh.19104 |
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