دورية أكاديمية
The CSR-1 endogenous RNAi pathway ensures accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans.
| العنوان: | The CSR-1 endogenous RNAi pathway ensures accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans. |
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| المؤلفون: | Fassnacht, Christina, Tocchini, Cristina, Kumari, Pooja, Gaidatzis, Dimos, Stadler, Michael B, Ciosk, Rafal |
| المصدر: | 1553-7390. |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2019 |
| المجموعة: | Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
| الوصف: | Endogenous RNAi (endoRNAi) is a conserved mechanism for fine-tuning gene expression. In the nematode Caenorhabditis elegans, several endoRNAi pathways are required for the successful development of reproductive cells. The CSR-1 endoRNAi pathway promotes germ cell development, primarily by facilitating the expression of germline genes. In this study, we report a novel function for the CSR-1 pathway in preventing premature activation of embryonic transcription in the developing oocytes, which is accompanied by a general Pol II activation. This CSR-1 function requires its RNase activity, suggesting that, by controlling the levels of maternal mRNAs, CSR-1-dependent endoRNAi contributes to an orderly reprogramming of transcription during the oocyte-to-embryo transition. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://urn.nb.no/URN:NBN:no-74577Test; Fassnacht, Christina Tocchini, Cristina Kumari, Pooja Gaidatzis, Dimos Stadler, Michael B Ciosk, Rafal . The CSR-1 endogenous RNAi pathway ensures accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans. PLoS Genetics. 2018; http://hdl.handle.net/10852/71445Test; 1652001; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS Genetics&rft.volume=&rft.spage=&rft.date=2018; PLoS Genetics; https://doi.org/10.1371/journal.pgen.1007252Test; URN:NBN:no-74577; Fulltext https://www.duo.uio.no/bitstream/handle/10852/71445/1/The%2BCSR-1%2Bendogenous%2BRNAi%2Bpathway-journal.pgen.1007252.pdfTest |
| DOI: | 10.1371/journal.pgen.1007252 |
| الإتاحة: | https://doi.org/10.1371/journal.pgen.1007252Test http://hdl.handle.net/10852/71445Test http://urn.nb.no/URN:NBN:no-74577Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.C427F004 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pgen.1007252 |
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