التفاصيل البيبلوغرافية
| العنوان: |
Autophagy Mediates the Degradation of Plant ESCRT Component FREE1 in Response to Iron Deficiency |
| المؤلفون: |
Tianrui Zhang, Zhidan Xiao, Chuanliang Liu, Chao Yang, Jiayi Li, Hongbo Li, Caiji Gao, Wenjin Shen |
| المصدر: |
International Journal of Molecular Sciences; Volume 22; Issue 16; Pages: 8779 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
protein degradation, autophagy, ESCRT complex, FREE1, iron-deficiency |
| جغرافية الموضوع: |
agris |
| الوصف: |
Multivesicular body (MVB)-mediated endosomal sorting and macroautophagy are the main pathways mediating the transport of cellular components to the vacuole and are essential for maintaining cellular homeostasis. The interplay of these two pathways remains poorly understood in plants. In this study, we show that FYVE DOMAIN PROTEIN REQUIRED FOR ENDOSOMAL SORTING 1 (FREE1), which was previously identified as a plant-specific component of the endosomal sorting complex required for transport (ESCRT), essential for MVB biogenesis and plant growth, can be transported to the vacuole for degradation in response to iron deficiency. The vacuolar transport of ubiquitinated FREE1 protein is mediated by the autophagy pathway. As a consequence, the autophagy deficient mutants, atg5-1 and atg7-2, accumulate more endogenous FREE1 protein and display hypersensitivity to iron deficiency. Furthermore, under iron-deficient growth condition autophagy related genes are upregulated to promote the autophagic degradation of FREE1, thereby possibly relieving the repressive effect of FREE1 on iron absorption. Collectively, our findings demonstrate a unique regulatory mode of protein turnover of the ESCRT machinery through the autophagy pathway to respond to iron deficiency in plants. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Molecular Plant Sciences; https://dx.doi.org/10.3390/ijms22168779Test |
| DOI: |
10.3390/ijms22168779 |
| الإتاحة: |
https://doi.org/10.3390/ijms22168779Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.C3C2C4A3 |
| قاعدة البيانات: |
BASE |
