رسالة جامعية
PET/MRI and multiple myeloma: determination of the optimal hybrid and functional imaging protocol for 18F-FDG-PET/MRI to detect and assess bone marrow involvement of patients with monoclonal gammopathy ; TEP/IRM et myélome multiple : détermination du protocole optimal d’imagerie hybride et fonctionnelle en TEP/IRM au 18F-FDG pour détecter et évaluer l’atteinte osseuse initiale des patients présentant une gammapathie monoclonale
| العنوان: | PET/MRI and multiple myeloma: determination of the optimal hybrid and functional imaging protocol for 18F-FDG-PET/MRI to detect and assess bone marrow involvement of patients with monoclonal gammopathy ; TEP/IRM et myélome multiple : détermination du protocole optimal d’imagerie hybride et fonctionnelle en TEP/IRM au 18F-FDG pour détecter et évaluer l’atteinte osseuse initiale des patients présentant une gammapathie monoclonale |
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| المؤلفون: | Burns, Robert Edward |
| المساهمون: | UFR Médecine Santé - Université Paris Cité (UFR Médecine UPCité), Université Paris Cité (UPCité), Sébastien Mule |
| المصدر: | https://dumas.ccsd.cnrs.fr/dumas-03637708Test ; Médecine humaine et pathologie. 2020. |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | PET/MRI, Hybrid Imaging, Monoclonal Gammopathy, WholeBbody Diffusion, Whole-Body MRI, 18F-FDG-PET, TEP/IRM, Imagerie hybride, Myélome multiple, Gammapathie monoclonale, Diffusion corps entier, 18F-FDG-TEP, MESH: Multiple myeloma, MESH: Paraproteinemias, MESH: Multimodal imaging, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | Purpose: PET/MRI can provide simultaneous whole-body (WB) acquisition of T1,T2DIXON, Diffusion Weighted Images (DWI), Dynamic Contrast-Enhanced (DCE), and FDG-PET sequences. The objective of this study was to assess and compare the diagnostic performance of 4 combinations of these sequences for baseline staging of patients with monoclonal gammopathies (MG). Materials and methods: 104 patients with MG were included in this IRB approved study. Readers reviewed initial PET/MRIs for the presence of focal lesions (FL) and bone marrow infiltration (BMI) using 4 different image datasets: WB-MRI (including DWI), 3DT1-PET, WB-PET/MRI and WB-DCE-PET/MRI. A reference standard was established by a panel review of all baseline and follow-up imaging, biological and pathological data. The diagnostic performance for each image dataset to detect FL and BMI were evaluated and compared (Fisher’s exact test). Results: The sensitivity, specificity and accuracy for FL of WB-MRI was 87, 97 and 92%; of 3DT1-PET was 78, 97, and 95%; of WB-PET-MRI was 93, 97, and 95%; WB-DCE-PET-MRI was 93, 97, and 95%. The sensitivity of WB-PET-MRI and WB-DCE-PET-MRI were superior to 3DT1-PET (p=0,036) without decreasing specificity. The sensitivity, specificity and accuracy of WB-MRI for BMI was 91, 80 and 85% ; of 3DT1-PET was 53, 89, and 74% ; of WB-PET-MRI was 98, 66, and 79% ; of WB-DCE-PET-MRI was 98, 59, and 75%. 3DT1-PET lacked sensitivity compared to all other datasets (p<0.0001). WB-MRI had better sensitivity than 3DT1-PET (p<0.001) and specificity than DCE-PET/MRI (p<0.001). Conclusion: PET/MRI should combine both WB bone marrow dedicated MRI and FDG PET images with no added value of DCE for baseline staging. ; L’objectif de cette étude était d'évaluer et de comparer les performances diagnostiques de 4 combinaisons de séquences en TEP/IRM pour le bilan initial des patients atteints de gammapathies monoclonales (GM). Matériel et Méthodes :104 patients avec une GM ont été inclus dans cette étude approuvée par l'IRB. Les lecteurs ont ... |
| نوع الوثيقة: | master thesis |
| اللغة: | French |
| العلاقة: | dumas-03637708; https://dumas.ccsd.cnrs.fr/dumas-03637708Test; https://dumas.ccsd.cnrs.fr/dumas-03637708/documentTest; https://dumas.ccsd.cnrs.fr/dumas-03637708/file/ThEXE_Robert_Edward_BURNS_DUMAS.pdfTest |
| الإتاحة: | https://dumas.ccsd.cnrs.fr/dumas-03637708Test https://dumas.ccsd.cnrs.fr/dumas-03637708/documentTest https://dumas.ccsd.cnrs.fr/dumas-03637708/file/ThEXE_Robert_Edward_BURNS_DUMAS.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-nc-ndTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.C3AF7DD4 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |