التفاصيل البيبلوغرافية
| العنوان: |
A prognostic score based on B cell and plasma cell densities compared to T cell densities in colorectal cancer |
| المؤلفون: |
Karjalainen, Henna, Sirniö, Päivi, Tuomisto, Anne, Mäkinen, Markus J., Väyrynen, Juha P. |
| المساهمون: |
Syöpäsäätiö, University of Oulu including Oulu University Hospital |
| المصدر: |
International Journal of Colorectal Disease ; volume 38, issue 1 ; ISSN 1432-1262 |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Gastroenterology |
| الوصف: |
Purpose The purpose of this study was to compare a B cell/plasma cell–based scoring system to T cell score and evaluate their prognostic value in colorectal cancer. Methods We used immunohistochemistry to analyze the expression of CD20, CD138, CD3, and CD8 in 221 colorectal cancer patients. CD20+ B cell and CD138+ plasma cell densities in the tumor center and invasive margin were calculated and converted into a B cell/plasma cell score. T cell score was defined similarly, using CD3+ and CD8+ T cell densities. Their associations with tumor and patient characteristics and survival were analyzed. Results Kaplan–Meier analysis showed a high B cell/plasma cell score was associated with a tendency towards longer survival ( p = 0.089), but no statistically significant association was found. High T cell score associated with longer cancer-specific survival in Kaplan–Meier analysis and multivariable Cox regression analysis ( p < 0.001). Additionally, high T cell score associated with lower disease stage ( p < 0.001) and lesser lymphovascular invasion ( p = 0.020). Conclusions High T cell score is associated with longer survival and clinicopathological factors typical to less aggressive tumors. This study did not support the additional prognostic value of B cell/plasma cell quantification. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1007/s00384-023-04322-y |
| DOI: |
10.1007/s00384-023-04322-y.pdf |
| DOI: |
10.1007/s00384-023-04322-y/fulltext.html |
| الإتاحة: |
https://doi.org/10.1007/s00384-023-04322-yTest |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.C381CD0E |
| قاعدة البيانات: |
BASE |
