دورية أكاديمية
An Overview on the Use of miRNAs as Possible Forensic Biomarkers for the Diagnosis of Traumatic Brain Injury
| العنوان: | An Overview on the Use of miRNAs as Possible Forensic Biomarkers for the Diagnosis of Traumatic Brain Injury |
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| المؤلفون: | Albano, Giuseppe Davide, Stassi, Chiara, Argo, Antonina, Zerbo, Stefania |
| المساهمون: | Albano, Giuseppe Davide, Stassi, Chiara, Argo, Antonina, Zerbo, Stefania |
| سنة النشر: | 2023 |
| المجموعة: | IRIS Università degli Studi di Palermo |
| مصطلحات موضوعية: | traumatic brain injury, miRNA, forensic, autopsy, biomarkers, Settore MED/43 - Medicina Legale |
| الوصف: | Determining the cause of death is one of the main goals of forensic pathology. However, conditions can occur in which common approaches—external inspection, autopsy, histology, etc.—might not be conclusive. With the advancement of molecular biology, several investigative techniques have been developed over the years, and the application as approaches complementary to routine procedures has proved useful in these cases. In this context, microRNA (miRNA) profiling has attracted increasing interest due to these molecules’ ability to regulate physiological and pathological processes. The evidence of differential miRNA expression in both animal models and human samples of traumatic brain injury (TBI) has laid the basis for comprehension of the underlying pathophysiological mechanisms, thus allowing us to identify some of them as possible TBI diagnostic biomarkers. The present narrative review aims to explore the primary miRNAs involved in the mechanisms underlying TBI, which could be considered for future evaluation as possible markers in a post mortem setting. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000970277700001; volume:24; issue:7; numberofpages:14; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; https://hdl.handle.net/10447/585470Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85152320911 |
| DOI: | 10.3390/ijms24076503 |
| الإتاحة: | https://doi.org/10.3390/ijms24076503Test https://hdl.handle.net/10447/585470Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C373DE91 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms24076503 |
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