دورية أكاديمية
Diffusion-sensitized magnetic resonance imaging highlights placental microstructural damage in patients with previous SARS-CoV-2 pregnancy infection
| العنوان: | Diffusion-sensitized magnetic resonance imaging highlights placental microstructural damage in patients with previous SARS-CoV-2 pregnancy infection |
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| المؤلفون: | Ercolani, Giada, Capuani, Silvia, Maiuro, Alessandra, Celli, Veronica, Grimm, Robert, Di Mascio, Daniele, Porpora, Maria Grazia, Catalano, Carlo, Brunelli, Roberto, Giancotti, Antonella, Manganaro, Lucia |
| المساهمون: | Ercolani, Giada, Capuani, Silvia, Maiuro, Alessandra, Celli, Veronica, Grimm, Robert, Di Mascio, Daniele, Porpora, Maria Grazia, Catalano, Carlo, Brunelli, Roberto, Giancotti, Antonella, Manganaro, Lucia |
| سنة النشر: | 2023 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | Diffusion MRI, IVIM, Microstructural damage, Placenta, SARS-CoV-2 |
| الوصف: | Introduction: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been a major global health problem since December 2019. This work aimed to investigate whether pregnant women's mild and moderate SARS-CoV-2 infection was associated with microstructural and vascular changes in the placenta observable in vivo by Intravoxel Incoherent Motion (IVIM) at different gestational ages (GA). Methods: This was a retrospective, nested case-control of pregnant women during the SARS-CoV-2 pandemic (COVID-19 group, n=14) compared to pre-pandemic healthy controls (n=19). MRI IVIM protocol at 1.5T was constituted of diffusion-weighted (DW) images with TR/TE=3100/76ms and 10b-values (0,10,30,50,75,100,200,400,700,1000s/mm2). Differences between IVIM parameters D (diffusion), and f (fractional perfusion) quantified in the two groups were evaluated using the ANOVA test with Bonferroni correction and linear correlation between IVIM metrics and GA, COVID-19 duration, the delay time between a positive SARS-CoV-2 test and MRI examination (delay-time exam+) was studied by Pearson-test. Results: D was significantly higher in the COVID-19 placentas compared to that of the age-matched healthy group (p<0.04 in fetal and p<0.007 in maternal site). No significant difference between f values was found in the two groups suggesting no-specific microstructural damage with no perfusion alteration (potentially quantified by f) in mild/moderate SARS-Cov-2 placentas. A significant negative correlation was found between D and GA in the COVID-19 placentas whereas no significant correlation was found in the control placentas reflecting a possible accelerated senescence process due to COVID-19. Discussion: We report impaired microstructural placental development during pregnancy and the absence of perfusion-IVIM parameter changes that may indicate no perfusion changing through microvessels and microvilli in the placentas of pregnancies with mild/moderate SARS-Cov-2 after reaching negativity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/38052124; info:eu-repo/semantics/altIdentifier/wos/WOS:001135330200001; volume:145; firstpage:38; lastpage:44; numberofpages:7; journal:PLACENTA; https://hdl.handle.net/11573/1693888Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85179044378 |
| DOI: | 10.1016/j.placenta.2023.11.017 |
| الإتاحة: | https://doi.org/10.1016/j.placenta.2023.11.017Test https://hdl.handle.net/11573/1693888Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C361BE20 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.placenta.2023.11.017 |
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