دورية أكاديمية

Diabetic retinopathy is associated with mortality and cardiovascular disease incidence: The EURODIAB Prospective Complications Study

التفاصيل البيبلوغرافية
العنوان: Diabetic retinopathy is associated with mortality and cardiovascular disease incidence: The EURODIAB Prospective Complications Study
المؤلفون: van Hecke, M.V., Dekker, J.M., Stehouwer, C.D.A., Polak, B.C.P., Fuller, J.H., Sjolie, A.K., Kofinis, A., Rottiers, R., Porta, M., Chaturvedi, N.
المصدر: van Hecke , M V , Dekker , J M , Stehouwer , C D A , Polak , B C P , Fuller , J H , Sjolie , A K , Kofinis , A , Rottiers , R , Porta , M & Chaturvedi , N 2005 , ' Diabetic retinopathy is associated with mortality and cardiovascular disease incidence: The EURODIAB Prospective Complications Study ' , Diabetes Care , vol. 28 , pp. 1383-1389 . https://doi.org/10.2337/diacare.28.6.1383Test
سنة النشر: 2005
المجموعة: Maastricht University Research Publications
الوصف: OBJECTIVE - To study the relationship of nonproliferative and proliferative retinopathy with all-cause mortality and cardiovascular disease (CVD) incidence in type 1 diabetic patients and, additionally, the role of cardiovascular risk factors in these associations. RESEARCH DESIGN AND METHODS - This prospective study included 2,237 type 1 diabetic patients from 31 centers in 16 European countries at baseline, aged 15-60 years, who were examined for retinopathy by taking two-field 45 degrees fundus photographs, which were centrally graded. Mortality and cardiovascular morbidity follow-up was assessed 6-8 years after baseline examination according to a standardized protocol. RESULTS - After 7.9 years of follow-up, 64 patients had died and 128 patients had incident CVD. The age- and sex-adjusted hazard ratios (HRs) of all-cause mortality were 1.45 (95% CI 0.71-2.96) and 4.16 (1.96 - 8.84) in patients with nonproliferative and proliferative retinopathy at baseline, respectively. Adjustments for cardiovascular risk factors completely obliterated the association with nonproliferative retinopathy, whereas the association with proliferative retinopathy remained twofold increased, although nonsignificant. The age- and sex-adjusted HRs of incident CVD were 1.73 (1.15-2.60) and 2.05 (1.22-3.45) in patients with nonproliferative and proliferative retinopathy, respectively. After adjustments for cardiovascular risk factors, both associations were attenuated and lost statistical significance. CONCLUSIONS - This study shows that type 1 diabetic patients with nonproliferative or proliferative retinopathy have an increased risk for all-cause mortality and incident CVD. The presence of cardiovascular risk factors explained the associations to a large extent, except for the associations with proliferative retinopathy, which suggests that other shared mechanisms may be involved.
نوع الوثيقة: article in journal/newspaper
اللغة: English
DOI: 10.2337/diacare.28.6.1383
الإتاحة: https://doi.org/10.2337/diacare.28.6.1383Test
https://cris.maastrichtuniversity.nl/en/publications/6995076a-3896-4593-9f9b-62aa9d89c22cTest
حقوق: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.C3408818
قاعدة البيانات: BASE