دورية أكاديمية
Reduced foveal cone density in early idiopathic macular telangiectasia
| العنوان: | Reduced foveal cone density in early idiopathic macular telangiectasia |
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| المؤلفون: | Hongxin Song, Ethan A Rossi |
| المصدر: | BMJ Open Ophthalmology, Vol 6, Iss 1 (2021) |
| بيانات النشر: | BMJ Publishing Group |
| سنة النشر: | 2021 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Ophthalmology, RE1-994 |
| الوصف: | Objective Idiopathic macular telangiectasia (MacTel) is considered primarily a vascular disease affecting juxtafoveal retinal capillaries. However, recent evidence suggests that neuronal changes may occur early in disease development. We used high-resolution adaptive optics retinal imaging to elucidate the foveal cone photoreceptor changes at a cellular level in patients with MacTel.Methods and analysis We used adaptive optics scanning light ophthalmoscopy (AOSLO) to evaluate the foveal cone photoreceptors in the less-affected eye of patients with asymmetric MacTel. AOSLO images of cone photoreceptors were obtained in a 4°×4° area centred on the foveola. Individual cone positions were identified within a 2°×2° area centred on the fovea, using semiautomatic cone marking software with manual correction, permitting calculation of a map of cone density.Results In all participants, one eye was affected with MacTel, the fellow eye was clinically normal or near normal, with visual acuity of 20/25 or better and subtle angiographic leakage. The foveal cone mosaics were continuous with tight packing and cones exhibited normal reflectivity. However, cone density was significantly lower for all participants (mean=80 733 cones/mm2) within 0.5° than the cone density previously reported for normal eyes.Conclusions Foveal cone density is lower than normal in the clinically less-affected eyes of patients with asymmetric MacTel. This suggests that cone photoreceptor loss may precede classic obvious vascular changes in idiopathic MacTel. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2397-3269 |
| العلاقة: | https://bmjophth.bmj.com/content/6/1/e000603.fullTest; https://doaj.org/toc/2397-3269Test; https://doaj.org/article/f8219a5c607f4ddfade69a888fdbd926Test |
| DOI: | 10.1136/bmjophth-2020-000603 |
| الإتاحة: | https://doi.org/10.1136/bmjophth-2020-000603Test https://doaj.org/article/f8219a5c607f4ddfade69a888fdbd926Test |
| رقم الانضمام: | edsbas.C2DAA7CB |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23973269 |
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| DOI: | 10.1136/bmjophth-2020-000603 |