التفاصيل البيبلوغرافية
| العنوان: |
Paraoxonase 1 and atrial fibrillation: Is there a relationship? |
| المؤلفون: |
Istratoaie, Sabina, Boroş, Bianca, Vesa, Ştefan Cristian, Maria Pop, Raluca, Cismaru, Gabriel, Pop, Dana, Vasile Milaciu, Mircea, Ciumărnean, Lorena, Văcăraş, Vitalie, Dana Buzoianu, Anca |
| المصدر: |
Medicine ; volume 101, issue 46, page e31553 ; ISSN 1536-5964 |
| بيانات النشر: |
Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: |
2022 |
| الوصف: |
Atrial fibrillation (AF) is associated with oxidative stress and inflammation. Paraoxonase-1 (PON1), circulates in blood bound to high-density lipoproteins and reduces systemic oxidative stress. The aim of this study was to evaluate PON1 serum concentration and PON1 arylesterase activity (AREase) in patients with AF. We studied a group of 67 patients with symptomatic paroxysmal or persistent AF admitted for cardioversion and a control group of 59 patients without AF. Clinical parameters, lipid profile, PON1 concentration and AREase were evaluated. A significant difference in serum PON1 concentration and in AREase was found among the two groups. In a multivariate linear regression model, the presence of AF was associated with low PON1 concentration ( P = .022). The body mass index was also independently associated with PON1 values ( P < .001). Only the high-density lipoproteins-cholesterol level was independently associated with AREase ( P = .002). PON1 serum concentrations and AREase were diminished in patients with AF, and the presence of AF was independently associated with low PON1 values. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1097/md.0000000000031553 |
| DOI: |
10.1097/MD.0000000000031553 |
| الإتاحة: |
https://doi.org/10.1097/md.0000000000031553Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: |
edsbas.C28929E5 |
| قاعدة البيانات: |
BASE |
