دورية أكاديمية
Health-related quality of life in patients with microsatellite instability-high or mismatch repair deficient metastatic colorectal cancer treated with first-line pembrolizumab versus chemotherapy (KEYNOTE-177):an open-label, randomised, phase 3 trial
| العنوان: | Health-related quality of life in patients with microsatellite instability-high or mismatch repair deficient metastatic colorectal cancer treated with first-line pembrolizumab versus chemotherapy (KEYNOTE-177):an open-label, randomised, phase 3 trial |
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| المؤلفون: | Andre, Thierry, Amonkar, Mayur, Norquist, Josephine M, Shiu, Kai-Keen, Kim, Tae Won, Jensen, Benny Vittrup, Jensen, Lars Henrik, Punt, Cornelis J A, Smith, Denis, Garcia-Carbonero, Rocio, Sevilla, Isabel, De La Fouchardiere, Christelle, Rivera, Fernando, Elez, Elena, Diaz, Luis A, Yoshino, Takayuki, Van Cutsem, Eric, Yang, Ping, Farooqui, Mohammed, Le, Dung T |
| المصدر: | Andre , T , Amonkar , M , Norquist , J M , Shiu , K-K , Kim , T W , Jensen , B V , Jensen , L H , Punt , C J A , Smith , D , Garcia-Carbonero , R , Sevilla , I , De La Fouchardiere , C , Rivera , F , Elez , E , Diaz , L A , Yoshino , T , Van Cutsem , E , Yang , P , Farooqui , M & Le , D T 2021 , ' Health-related quality of life in patients .... |
| سنة النشر: | 2021 |
| المجموعة: | University of Southern Denmark: Research Output / Syddansk Universitet |
| مصطلحات موضوعية: | Adult, Aged, Antibodies, Monoclonal, Humanized/therapeutic use, Brain Neoplasms/drug therapy, Colorectal Neoplasms/drug therapy, DNA Mismatch Repair, Female, Humans, Male, Microsatellite Instability, Middle Aged, Neoplasm Metastasis, Neoplastic Syndromes, Hereditary/drug therapy, Quality of Life |
| الوصف: | BACKGROUND: In the KEYNOTE-177 study, pembrolizumab monotherapy provided statistically significant and clinically meaningful improvements in progression-free survival versus chemotherapy as first-line treatment in patients with microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer. To further support the efficacy and safety findings of the KEYNOTE-177 study, results of the health-related quality of life (HRQOL) analyses are reported here. METHODS: KEYNOTE-177 is an open-label, randomised, phase 3 trial being done at 192 cancer centres in 23 countries, in patients aged 18 years and older with microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer, with an Eastern Cooperative Oncology Group performance status of 0 or 1, and who had not received previous systemic therapy for metastatic disease. Eligible patients were randomly assigned (1:1) centrally by use of interactive voice response or integrated web response technology to receive pembrolizumab 200 mg intravenously every 3 weeks or investigator's choice chemotherapy (mFOLFOX6 [leucovorin, fluorouracil, and oxaliplatin] or FOLFIRI [leucovorin, fluorouracil, and irinotecan] intravenously every 2 weeks with or without intravenous bevacizumab or cetuximab). Patients and investigators were not masked to treatment assignment. The primary endpoints were progression-free survival (previously reported) and overall survival (data to be reported at the time of the final analysis). HRQOL outcomes were evaluated as prespecified exploratory endpoints. The analysis population comprised all randomly assigned patients who received at least one dose of study treatment and completed at least one HRQOL assessment. HRQOL outcomes were mean change from baseline to prespecified week 18 in European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and EORTC Quality of Life Questionnaire-Colorectal 29 (EORTC QLQ-CR29) scale and item scores, and in the EuroQoL 5 ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://portal.findresearcher.sdu.dk/da/publications/69d10cbc-072e-484a-8796-e181979479aaTest |
| DOI: | 10.1016/S1470-2045(21)00064-4 |
| الإتاحة: | https://doi.org/10.1016/S1470-2045Test(21)00064-4 https://portal.findresearcher.sdu.dk/da/publications/69d10cbc-072e-484a-8796-e181979479aaTest https://findresearcher.sdu.dk/ws/files/182041028/Andre_KN177_PRO_revised_MS_Final.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C26D4842 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S1470-2045(21)00064-4 |
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