دورية أكاديمية
Epidemiological trends in invasive aspergillosis in France: the SAIF network (2005-2007).
| العنوان: | Epidemiological trends in invasive aspergillosis in France: the SAIF network (2005-2007). |
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| المؤلفون: | Lortholary, Olivier, Gangneux, Jean-Pierre, Sitbon, Karine, Lebeau, Bernadette, de Monbrison, Frédérique, Le Strat, Yann, Coignard, Bruno, Dromer, Françoise, Bretagne, Stéphane |
| المساهمون: | Centre d'infectiologie Necker-Pasteur CHU Necker, Institut Pasteur Paris (IP)-Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Mycologie moléculaire, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence Mycologie et Antifongiques-Mycologie Moléculaire (CNRMA), Institut Pasteur Paris (IP), Signalisation et Réponses aux Agents Infectieux et Chimiques (SeRAIC), Université de Rennes (UR), Service de Parasitologie-Mycologie Rennes, Université de Rennes (UR)-Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Laboratoire de parasitologie-mycologie, Centre Hospitalier Universitaire CHU Grenoble (CHUGA), Laboratoire de Parasitologie-Mycologie, Centre Hospitalo-Universitaire de Lyon, Département des maladies infectieuses, Institut de Veille Sanitaire (INVS), Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Biologie moléculaire et immunologie parasitaires et fongiques (BIPAR), École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Normandie, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut de Veille Sanitaire |
| المصدر: | ISSN: 1198-743X. |
| بيانات النشر: | HAL CCSD Elsevier for the European Society of Clinical Microbiology and Infectious Diseases |
| سنة النشر: | 2011 |
| المجموعة: | Université de Rennes 1: Publications scientifiques (HAL) |
| مصطلحات موضوعية: | Epidemiology, galactomannan, invasive aspergillosis, outcome, voriconazole, MESH: Adolescent, MESH: Adult, MESH: Humans, MESH: Immunocompromised Host, MESH: Incidence, MESH: Invasive Pulmonary Aspergillosis, MESH: Male, MESH: Mannans, MESH: Middle Aged, MESH: Prospective Studies, MESH: Risk Factors, MESH: Seasons, MESH: Aged, MESH: Young Adult, 80 and over, MESH: Antifungal Agents, MESH: Aspergillus, MESH: Drug Therapy, Combination, MESH: Female, MESH: France, MESH: Hospitals, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology |
| الوصف: | International audience ; A prospective (2005-2007) hospital-based multicentre surveillance of EORTC/MSG-proven or probable invasive aspergillosis (IA) cases whatever the underlying diseases was implemented in 12 French academic hospitals. Admissions per hospital and transplantation procedures were obtained. Cox regression models were used to determine risk factors associated with the 12-week overall mortality. With 424 case-patients included, the median incidence/hospital was 0.271/10(3) admissions (range 0.072-0.910) without significant alteration of incidence and seasonality over time. Among the 393 adults (62% men, 56 years (16-84 years)), 15% had proven IA, 78% haematological conditions, and 92.9% had lung involvement. Acute leukaemia (34.6%) and allogeneic stem cell transplantation (21.4%) were major host factors, together with chronic lymphoproliferative disorders (21.6%), which emerged as a new high-risk group. The other risk host factors consisted of solid organ transplantation (8.7%), solid tumours (4.3%), systemic inflammatory diseases (4.6%) and chronic respiratory diseases (2.3%). Serum galactomannan tests were more often positive (≥69%) for acute leukaemia and allogeneic stem cell transplantation than for the others (<42%; p <10(-3)). When positive (n = 245), cultures mainly yielded Aspergillus fumigatus (79.7%). First-line antifungal therapy consisted of voriconazole, caspofungin, lipid formulations of amphotericin, or any combination therapy (52%, 14%, 8% and 19.9%, respectively). Twelve-week overall mortality was 44.8% (95% CI, 39.8-50.0); it was 41% when first-line therapy included voriconazole and 60% otherwise (p <0.001). Independent factors for 12-week mortality were older age, positivity for both culture and galactomannan and central nervous system or pleural involvement, while any strategy containing voriconazole was protective. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/21668573; hal-00680990; https://hal.science/hal-00680990Test; PRODINRA: 317243; PUBMED: 21668573; WOS: 000297012200026 |
| DOI: | 10.1111/j.1469-0691.2011.03548.x |
| الإتاحة: | https://doi.org/10.1111/j.1469-0691.2011.03548.xTest https://hal.science/hal-00680990Test |
| رقم الانضمام: | edsbas.C230DD08 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1469-0691.2011.03548.x |
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