دورية أكاديمية
The Effect of Matrix Metalloproteinase-3 on the Prognosis and Biological Behaviour of Meningiomas
| العنوان: | The Effect of Matrix Metalloproteinase-3 on the Prognosis and Biological Behaviour of Meningiomas |
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| المؤلفون: | Karaarslan, Numan, Gürbüz, Mehmet Sabri, Çalışkan, Tezcan, Ayan, Erdoğan, Vardar Aker, Fugen, Berkman, Mehmet Zafer |
| بيانات النشر: | Turkish Neurosurgical Soc |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Grade, Ki-67 Proliferation index, Matrix Metalloproteinase-3, Meningioma, Expression, Apoptosis, Ki-67, Angiogenesis, Recurrence, Target, Roles, Mmp-9 |
| الوصف: | AIM: To analyse the effect of MMP-3 (Matrix Metalloproteinase Enzyme-3)-one of the extracellular matrix proteins-on the prognosis and biological behaviour of meningiomas. MATERIAL and METHODS: 79 cases of meningioma that were operated in our clinic between 2005 and 2010 were retrospectively analysed. Age, sex, preoperative peritumoral edema, histological subtype, grade, Ki-67 expression, MMP-3 staining pattern and recurrence rate were analysed. Pathological preparations were graded according to the WHO (World Health Organisation) 2007 grading system. RESULTS: Of the MMP-III positive cases; 24 cases (60%) were grade I, 16 cases were grade II. The MMP-3 staining pattern was significantly positive (80%) in grade II meningioma. 14 of the MMP-3 positive cases were atypical meningiomas. Of the 20 cases with high Ki-67 proliferation index (PI), 12 cases (60%) were MMP-3 positive and 8 cases (40%) were MMP-3 negative. Rates of recurrence and preoperative peritumoral edema were high in cases with MMP-3 positivity. CONCLUSION: In this study it was determined that MMP-3 positivity has a strong relationship with meningiomas having an aggressive character. MMP-3 may be used as a proliferation marker for biological behaviour, recurrence rate and prognosis of meningiomas. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1019-5149 |
| العلاقة: | Turkish Neurosurgery; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.5137/1019-5149.JTN.12807-14.1Test; https://hdl.handle.net/20.500.11776/8089Test; 26; 678; 683; WOS:000385338600004; 2-s2.0-85017078100 |
| DOI: | 10.5137/1019-5149.JTN.12807-14.1 |
| الإتاحة: | https://doi.org/20.500.11776/8089Test https://doi.org/10.5137/1019-5149.JTN.12807-14.1Test https://hdl.handle.net/20.500.11776/8089Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.C1F5F67F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10195149 |
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| DOI: | 10.5137/1019-5149.JTN.12807-14.1 |