دورية أكاديمية
MicroRNAs in Human Malignant Gliomas
| العنوان: | MicroRNAs in Human Malignant Gliomas |
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| المؤلفون: | Masahiro Mizoguchi, Yanlei Guan, Koji Yoshimoto, Nobuhiro Hata, Toshiyuki Amano, Akira Nakamizo, Tomio Sasaki |
| المصدر: | Journal of Oncology, Vol 2012 (2012) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2012 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | MicroRNA (miRNA) is a new class of small noncoding RNA molecules that regulate a wide spectrum of gene expression in a posttranscriptional manner. MiRNAs play crucial roles in tumorigenesis, angiogenesis, invasion, and apoptosis for various types of tumor. Recent studies have identified dysregulation of specific miRNAs in malignant gliomas. Global expression profiling of miRNAs has revealed several miRNAs clinically implicated in human glioblastomas. Some miRNAs are clearly associated with clinical outcome and chemo- and radio-therapy resistance in these tumors. Furthermore, miRNAs also regulate specific signaling pathways, including the critical core pathways in glioblastoma. As a result, miRNAs have the potential to affect the responses to molecular-targeted therapies. More recent studies have revealed that miRNAs might be associated with cancer stem cell properties, affecting tumor maintenance and progression. Recent investigation have revealed that miRNAs are not only biological markers with diagnostic implications, but also one of the most promising treatment targets in human glioblastoma. Herein, we summarized the novel insights of miRNAs into human malignant gliomas. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1687-8450 1687-8469 |
| العلاقة: | http://dx.doi.org/10.1155/2012/732874Test; https://doaj.org/toc/1687-8450Test; https://doaj.org/toc/1687-8469Test; https://doaj.org/article/aa52746e98924431836cd3c7349abc3dTest |
| DOI: | 10.1155/2012/732874 |
| الإتاحة: | https://doi.org/10.1155/2012/732874Test https://doaj.org/article/aa52746e98924431836cd3c7349abc3dTest |
| رقم الانضمام: | edsbas.C1E3DFC5 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16878450 16878469 |
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| DOI: | 10.1155/2012/732874 |