التفاصيل البيبلوغرافية
| العنوان: |
Coridius chinensis Extract Promotes Leydig Cell Endocrine Function Rescuing Testosterone Deficiency and Sexual Behavior Insufficiency in Manganese‐Exposed Rat |
| المؤلفون: |
Luo, Nanjian, Xiong, Keyi, Wang, Yong, Cen, Changhuo, Liu, Qiongyou, Wang, Fengyue, Hu, Yu, Hou, Xiaohui |
| المساهمون: |
Banihani, Saleem, Department of Education of Guizhou Province |
| المصدر: |
Andrologia ; volume 2024, issue 1 ; ISSN 0303-4569 1439-0272 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2024 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Coridius chinensis is a traditional Chinese medicinal insect, whose extract (CcE) is widely used for male reproductive disorders. Manganese (Mn 2+ ) as a heavy metal pollutant can cause toxicity to the reproductive system in mammals. Previous studies found that CcE can resist the apoptosis and oxidation by Mn 2+ exposed to repair the damage of seminiferous epithelium in rat. However, the therapeutic effect of CcE in the testicular stroma remains unclear. Our study found that the slow mating behaviors of capture, riding, insertion, and ejaculation with Mn 2+ exposure were improved by CcE treatment in male rat. The level of testosterone was significantly increased in CcE‐treated groups. Meanwhile, the damage about less area and cell number in testicular stroma due to Mn 2+ exposure was repaired after CcE treatment. Ultrastructure analysis of Leydig cells showed the larger mitochondria and more endoplasmic reticulum in Mn 2+ CcE groups became than that in Mn 2+ group. Further experiments showed that mRNA and protein level of steroidogenic‐related regulators (STAR, CYP11 α 1, and HSD3 β 1) were significantly decreased in Mn 2+ group and strongly upregulated occurred at medium concentration of CcE given. Taken together, our results provide a new insight of CcE in promoting testosterone production of Leydig cells to protect male reproductive behavior from Mn 2+ toxicity. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1155/2024/6629144 |
| الإتاحة: |
https://doi.org/10.1155/2024/6629144Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.C1C6301 |
| قاعدة البيانات: |
BASE |
