دورية أكاديمية
Corticosteroid-resistant immune-related adverse events: a systematic review
| العنوان: | Corticosteroid-resistant immune-related adverse events: a systematic review |
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| المؤلفون: | Daetwyler, Eveline, Wallrabenstein, Till, König, David, Cappelli, Laura C., Naidoo, Jarushka, Zippelius, Alfred, Läubli, Heinz |
| المصدر: | Journal for ImmunoTherapy of Cancer. - 12, 1 (2024) , e007409, ISSN: 2051-1426 |
| سنة النشر: | 2024 |
| المجموعة: | University of Freiburg: FreiDok |
| الوصف: | Immune checkpoint inhibitor (ICI) treatment has become an important therapeutic option for various cancer types. Although the treatment is effective, ICI can overstimulate the patient’s immune system, leading to potentially severe immune-related adverse events (irAEs), including hepatitis, colitis, pneumonitis and myocarditis. The initial mainstay of treatments includes the administration of corticosteroids. There is little evidence how to treat steroid-resistant (sr) irAEs. It is mainly based on small case series or single case reports. This systematic review summarizes available evidence about sr-irAEs. We conducted a systematic literature search in PubMed. Additionally, we included European Society for Medical Oncology, Society for Immunotherapy of Cancer, National Comprehensive Cancer Network and American Society of Clinical Oncology Guidelines for irAEs in our assessment. The study population of all selected publications had to include patients with cancer who developed hepatitis, colitis, pneumonitis or myocarditis during or after an immunotherapy treatment and for whom corticosteroid therapy was not sufficient. Our literature search was not restricted to any specific cancer diagnosis. Case reports were also included. There is limited data regarding life-threatening sr-irAEs of colon/liver/lung/heart and the majority of publications are single case reports. Most publications investigated sr colitis (n=26), followed by hepatitis (n=21), pneumonitis (n=17) and myocarditis (n=15). There is most data for mycophenolate mofetil (MMF) to treat sr hepatitis and for infliximab, followed by vedolizumab, to treat sr colitis. Regarding sr pneumonitis there is most data for MMF and intravenous immunoglobulins (IVIG) while data regarding infliximab are conflicting. In sr myocarditis, most evidence is available for the use of abatacept or anti-thymocyte globulin (ATG) (both with or without MMF) or ruxolitinib with abatacept. This review highlights the need for prompt recognition and treatment of sr hepatitis, colitis, ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | |
| اللغة: | English |
| العلاقة: | https://freidok.uni-freiburg.de/data/243584Test |
| DOI: | 10.1136/jitc-2023-007409 |
| الإتاحة: | https://doi.org/10.1136/jitc-2023-007409Test https://freidok.uni-freiburg.de/data/243584Test https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2435841Test https://freidok.uni-freiburg.de/dnb/download/243584Test |
| حقوق: | free |
| رقم الانضمام: | edsbas.C195D333 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/jitc-2023-007409 |
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