دورية أكاديمية
Early Anti-inflammatory and Pro-angiogenic Myocardial Effects of Intravenous Serelaxin Infusion for 72 H in an Experimental Rat Model of Acute Myocardial Infarction
| العنوان: | Early Anti-inflammatory and Pro-angiogenic Myocardial Effects of Intravenous Serelaxin Infusion for 72 H in an Experimental Rat Model of Acute Myocardial Infarction |
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| المؤلفون: | Sanchez-Mas, Jesus, Lax, Antonio, Asensio-Lopez, Mari C., Lencina, Miriam, Fernandez-del Palacio, Maria J., Soriano-Filiu, Angela, de Boer, Rudolf A., Pascual-Figal, Domingo A. |
| المصدر: | Sanchez-Mas , J , Lax , A , Asensio-Lopez , M C , Lencina , M , Fernandez-del Palacio , M J , Soriano-Filiu , A , de Boer , R A & Pascual-Figal , D A 2017 , ' Early Anti-inflammatory and Pro-angiogenic Myocardial Effects of Intravenous Serelaxin Infusion for 72 H in an Experimental Rat Model of Acute Myocardial Infarction ' , Journal of cardiovascular translational research , vol. 10 , no. 5-6 , pp. 460-469 . https://doi.org/10.1007/s12265-017-9761-1Test |
| سنة النشر: | 2017 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | Myocardial infarction, Left ventricular systolic dysfunction, Serelaxin, Remodeling, Fibrosis, RELAXIN PROTECTS, SWINE MODEL, HEART, INJURY, REPERFUSION, ISCHEMIA, THERAPY, REPAIR |
| الوصف: | Sprague Dawley rats were subjected to acute myocardial infarction (AMI) by permanent ligation of the left anterior descending coronary artery. At the time of AMI, a subcutaneous mini-osmotic pump was implanted and animals were randomized into three groups, according to the intravenous therapy received during the first 72 h: placebo-treated (saline), serelaxin10-treated (SRLX10 = 10 mu g/kg/day), or serelaxin30-treated (SRLX30 = 30 mu g/kg/day). Treatment with SRLX30 reduced the expression of inflammatory cytokines and chemokines, as well as the infiltration of macrophages, and increased the expression of pro-angiogenic markers and vessel density in the infarcted myocardium after 7 days. SRLX30 did not reduce early myocardial fibrosis but reduced myocardial levels of sST2 and galectin-3. No significant effects were observed with SRLX10 treatment. A significant correlation was observed between plasma levels of serelaxin and effect measures. The results suggest serelaxin has a protective effect in early processes of cardiac remodeling after AMI. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/664e2848-0e8e-44fb-b86d-e9c3c15e1c2cTest |
| DOI: | 10.1007/s12265-017-9761-1 |
| الإتاحة: | https://doi.org/10.1007/s12265-017-9761-1Test https://hdl.handle.net/11370/664e2848-0e8e-44fb-b86d-e9c3c15e1c2cTest https://research.rug.nl/en/publications/664e2848-0e8e-44fb-b86d-e9c3c15e1c2cTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C18723F6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s12265-017-9761-1 |
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