دورية أكاديمية
The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial
| العنوان: | The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial |
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| المؤلفون: | von Seidlein, Lorenz, Peto, Thomas, J, Landier, Jordi, Nguyen, Thuy-Nhien, Tripura, Rupam, Phommasone, Koukeo, Pongvongsa, Tiengkham, Lwin, Khin Maung, Keereecharoen, Lilly, Kajeechiwa, Ladda, Thwin, May Myo, Parker, Daniel, Wiladphaingern, Jacher, Nosten, Suphak, Proux, Stephane, Corbel, Vincent, Tuong-Vy, Nguyen, Phuc-Nhi, Truong Le, Son, Do Hung, Huong-Thu, Pham Nguyen, Tuyen, Nguyen Thi Kim, Tien, Nguyen Thanh, Dong, Le Thanh, Hue, Dao Van, Quang, Huynh Hong, Nguon, Chea, Davoeung, Chan, Rekol, Huy, Adhikari, Bipin, Henriques, Gisela, Phongmany, Panom, Suangkanarat, Preyanan, Jeeyapant, Atthanee, Vihokhern, Benchawan, van Der Pluijm, Rob, W, Lubell, Yoel, White, Lisa, J, Aguas, Ricardo, Promnarate, Cholrawee, Sirithiranont, Pasathorn, Malleret, Benoît, Renia, Laurent, Onsjö, Carl, Chan, Xin Hui, Chalk, Jeremy, Miotto, Olivo, Patumrat, Krittaya, Chotivanich, Kesinee, Hanboonkunupakarn, Borimas, Jittmala, Podjanee, Kaehler, Nils, Cheah, Phaik Yeong, Pell, Christopher, Dhorda, Mehul, Imwong, Mallika, Snounou, Georges, Mukaka, Mavuto, Peerawaranun, Pimnara, Lee, Sue, J, Simpson, Julie, A, Pukrittayakamee, Sasithon, Singhasivanon, Pratap, Grobusch, Martin, Cobelens, Frank, Smithuis, Frank, Newton, Paul, Thwaites, Guy, E, Day, Nicholas, E., Mayxay, Mayfong, Hien, Tran Tinh, Nosten, François, Dondorp, Arjen, White, Nicholas |
| المساهمون: | Mahidol Oxford Tropical Medicine Research Unit, University of Oxford-Mahidol University Bangkok, Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Oxford-Mahidol University Bangkok -Wellcome Trust, Shoklo Malaria Research Unit Mae Sot, Thailand (SMRU), University of Oxford-Mahidol University Bangkok -Wellcome Trust-University of Oxford-Mahidol University Bangkok -Wellcome Trust, Oxford University Clinical Research Unit Ho Chi Minh City (OUCRU), Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Mahidol University Bangkok -Mahosot Hospital, Savannakhet Provincial Health Department Lao People’s Democratic Republic, Savannakhet Province Lao People’s Democratic Republic, Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD France-Sud ), National Institute of Malariology, Parasitology and Entomology, National Institute of Malariology, Parasitology and Entomology Hanoi (NIMPE), Institute of Malariology, Parasitology, and Entomology Quy Nhon, Vietnam (IMPE), National Center for Parasitology, Entomology and Malaria Control Phnom Penh, Cambodia (CNM), Provincial Health Department Battambang, Cambodia (PHD), WWARN Asia Regional Centre Bangkok, Thailand, Mahidol University Bangkok, Institut des Maladies Emergentes et des Thérapies Innovantes (IMETI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Cochin (UMR_S567 / UMR 8104), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Department of Molecular Tropical Medicine and Genetics Bangkok, Thailand (Faculty of Tropical Medicine), Faculty of Tropical Medicine Bangkok, Thailand, Amsterdam Institute for Global Health & Development Amsterdam, The Netherlands, University of Oxford, Immunologie des Maladies Virales et Autoimmunes (IMVA - U1184), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre for Epidemiology and Biostatistics Victoria, Australia, University of Melbourne-Melbourne School of Population and Global Health Victoria, Australia, Department of Clinical Tropical Medicine Bangkok, Thailand (Faculty of Tropical Medicine), Faculty of Tropical Medicine, Department of Infectious Diseases Amsterdam, Netherlands (Academic Medical Center), University of Amsterdam Amsterdam (UvA)-Center for Tropical and Travel Medicine Amsterdam, Netherlands, Myanmar Oxford Clinical Research Unit Yangon, Myanmar |
| المصدر: | ISSN: 1549-1277. |
| بيانات النشر: | HAL CCSD Public Library of Science |
| سنة النشر: | 2019 |
| المجموعة: | HAL-CEA (Commissariat à l'énergie atomique et aux énergies alternatives) |
| مصطلحات موضوعية: | Plasmodium falciparum, Elimination, Mass Drug Administration, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | International audience ; Background: The emergence and spread of multidrug-resistant Plasmodium falciparum in the Greater Mekong Subregion (GMS) threatens global malaria elimination efforts. Mass drug administration (MDA), the presumptive antimalarial treatment of an entire population to clear the subclinical parasite reservoir, is a strategy to accelerate malaria elimination. We report a cluster randomised trial to assess the effectiveness of dihydroartemisinin-piperaquine (DP) MDA in reducing falciparum malaria incidence and prevalence in 16 remote village populations in Myanmar, Vietnam, Cambodia, and the Lao People’s Democratic Republic, where artemisinin resistance is prevalent.Methods and findings: After establishing vector control and community-based case management and following intensive community engagement, we used restricted randomisation within village pairs to select 8 villages to receive early DP MDA and 8 villages as controls for 12 months, after which the control villages received deferred DP MDA. The MDA comprised 3 monthly rounds of 3 daily doses of DP and, except in Cambodia, a single low dose of primaquine. We conducted exhaustive cross-sectional surveys of the entire population of each village at quarterly intervals using ultrasensitive quantitative PCR to detect Plasmodium infections. The study was conducted between May 2013 and July 2017. The investigators randomised 16 villages that had a total of 8,445 residents at the start of the study. Of these 8,445 residents, 4,135 (49%) residents living in 8 villages, plus an additional 288 newcomers to the villages, were randomised to receive early MDA; 3,790 out of the 4,423 (86%) participated in at least 1 MDA round, and 2,520 out of the 4,423 (57%) participated in all 3 rounds. The primary outcome, P. falciparum prevalence by month 3 (M3), fell by 92% (from 5.1% [171/3,340] to 0.4% [12/2,828]) in early MDA villages and by 29% (from 7.2% [246/3,405] to 5.1% [155/3,057]) in control villages. Over the following 9 months, the P. falciparum ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-02347151; https://hal.science/hal-02347151Test; https://hal.science/hal-02347151/documentTest; https://hal.science/hal-02347151/file/2019%20PLoSM%2016-e1002745%20Von%20Seidlein.pdfTest; PUBMEDCENTRAL: PMC6377128 |
| DOI: | 10.1371/journal.pmed.1002745 |
| الإتاحة: | https://doi.org/10.1371/journal.pmed.1002745Test https://hal.science/hal-02347151Test https://hal.science/hal-02347151/documentTest https://hal.science/hal-02347151/file/2019%20PLoSM%2016-e1002745%20Von%20Seidlein.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.C1308DB1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pmed.1002745 |
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