دورية أكاديمية
Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium: Table 1
| العنوان: | Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium: Table 1 |
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| المؤلفون: | Morris, Richard W, Taylor, Amy E, Fluharty, Meg E, Bjørngaard, Johan H, Åsvold, Bjørn Olav, Elvestad Gabrielsen, Maiken, Campbell, Archie, Marioni, Riccardo, Kumari, Meena, Korhonen, Tellervo, Männistö, Satu, Marques-Vidal, Pedro, Kaakinen, Marika, Cavadino, Alana, Postmus, Iris, Husemoen, Lise Lotte N, Skaaby, Tea, Ahluwalia, Tarun Veer Singh, Treur, Jorien L, Willemsen, Gonneke, Dale, Caroline, Wannamethee, S Goya, Lahti, Jari, Palotie, Aarno, Räikkönen, Katri, McConnachie, Alex, Padmanabhan, Sandosh, Wong, Andrew, Dalgård, Christine, Paternoster, Lavinia, Ben-Shlomo, Yoav, Tyrrell, Jessica, Horwood, John, Fergusson, David M, Kennedy, Martin A, Nohr, Ellen A, Christiansen, Lene, Kyvik, Kirsten Ohm, Kuh, Diana, Watt, Graham, Eriksson, Johan G, Whincup, Peter H, Vink, Jacqueline M, Boomsma, Dorret I, Davey Smith, George, Lawlor, Debbie, Linneberg, Allan, Ford, Ian, Jukema, J Wouter, Power, Chris, Hyppönen, Elina, Jarvelin, Marjo-Riitta, Preisig, Martin, Borodulin, Katja, Kaprio, Jaakko, Kivimaki, Mika, Smith, Blair H, Hayward, Caroline, Romundstad, Pål R, Sørensen, Thorkild IA, Munafò, Marcus R, Sattar, Naveed |
| بيانات النشر: | BMJ |
| سنة النشر: | 2015 |
| المجموعة: | University of Essex Research Repository |
| مصطلحات موضوعية: | H Social Sciences (General), RA0421 Public health. Hygiene. Preventive Medicine |
| الوصف: | Objectives: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity. Design: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes. Participants:148 731 current, former and neversmokers of European ancestry aged.16 years from 29 studies in the consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA). Primary outcome measures: Waist and hip circumferences, and waist-hip ratio. Results: The data included up to 66 809 never-smokers, 43 009 former smokers and 38 913 current daily cigarette smokers. Among current smokers, for each extra minor allele, the geometric mean was lower for waist circumference by -0.40% (95% CI -0.57% to -0.22%), with effects on hip circumference, waist-hip ratio and body mass index (BMI) being -0.31% (95% CI -0.42% to -0.19), -0.08% (-0.19% to 0.03%) and -0.74% (-0.96% to -0.51%), respectively. In contrast, among never-smokers, these effects were higher by 0.23% (0.09% to 0.36%), 0.17% (0.08% to 0.26%), 0.07% (-0.01% to 0.15%) and 0.35% (0.18% to 0.52%), respectively. When adjusting the three central adiposity measures for BMI, the effects among current smokers changed direction and were higher by 0.14% (0.05% to 0.22%) for waist circumference, 0.02% (-0.05% to 0.08%) for hip circumference and 0.10% (0.02% to 0.19%) for waist-hip ratio, for each extra minor allele. Conclusions: For a given BMI, a gene variant associated with increased cigarette consumption was associated with increased waist circumference. Smoking in an effort to control weight may lead to accumulation of central adiposity. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | http://repository.essex.ac.uk/15061/1/BMJ%20Open-2015-Morris-.pdfTest; Morris, Richard W and Taylor, Amy E and Fluharty, Meg E and Bjørngaard, Johan H and Åsvold, Bjørn Olav and Elvestad Gabrielsen, Maiken and Campbell, Archie and Marioni, Riccardo and Kumari, Meena and Korhonen, Tellervo and Männistö, Satu and Marques-Vidal, Pedro and Kaakinen, Marika and Cavadino, Alana and Postmus, Iris and Husemoen, Lise Lotte N and Skaaby, Tea and Ahluwalia, Tarun Veer Singh and Treur, Jorien L and Willemsen, Gonneke and Dale, Caroline and Wannamethee, S Goya and Lahti, Jari and Palotie, Aarno and Räikkönen, Katri and McConnachie, Alex and Padmanabhan, Sandosh and Wong, Andrew and Dalgård, Christine and Paternoster, Lavinia and Ben-Shlomo, Yoav and Tyrrell, Jessica and Horwood, John and Fergusson, David M and Kennedy, Martin A and Nohr, Ellen A and Christiansen, Lene and Kyvik, Kirsten Ohm and Kuh, Diana and Watt, Graham and Eriksson, Johan G and Whincup, Peter H and Vink, Jacqueline M and Boomsma, Dorret I and Davey Smith, George and Lawlor, Debbie and Linneberg, Allan and Ford, Ian and Jukema, J Wouter and Power, Chris and Hyppönen, Elina and Jarvelin, Marjo-Riitta and Preisig, Martin and Borodulin, Katja and Kaprio, Jaakko and Kivimaki, Mika and Smith, Blair H and Hayward, Caroline and Romundstad, Pål R and Sørensen, Thorkild IA and Munafò, Marcus R and Sattar, Naveed (2015) 'Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium: Table 1.' BMJ Open, 5 (8). e008808-e008808. ISSN 2044-6055 |
| الإتاحة: | http://repository.essex.ac.uk/15061Test/ http://repository.essex.ac.uk/15061/1/BMJ%20Open-2015-Morris-.pdfTest |
| حقوق: | cc_by |
| رقم الانضمام: | edsbas.C1201271 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |