دورية أكاديمية
Metabolomics reveals that fittest trail runners show a better adaptation of bioenergetic pathways
| العنوان: | Metabolomics reveals that fittest trail runners show a better adaptation of bioenergetic pathways |
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| المؤلفون: | Puigarnau Coma, Sílvia, Fernàndez, Anna, Obis Monné, Èlia, Jové Font, Mariona, Castañer Balcells, Marta, Pamplona Gras, Reinald, Portero Otín, Manuel, Camerino Foguet, Oleguer |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2022 |
| المجموعة: | Universitat de Lleida: Repositori Obert UdL |
| مصطلحات موضوعية: | Precision medicine, Aerobics, Physical activity, Mass spectrometry |
| الوصف: | Objectives: To analyze the effect in the blood metabolome of trail running, a demanding sport that takes place in the natural environment, places considerable strain on both muscles and joints. While metabolic responses to aerobic exercise have been analyzed in-depth, few studies have focused on trail running. Design: Observational study to analyze changes in 35 different metabolites - representative of aerobic exercise- induced by a simulated 21-km trail race with an uphill gradient of 1400 m. Methods: We performed a semiquantitative metabolomics study consisting of capillary blood microsampling and targeted screening with liquid chromatography and mass spectrometry to analyze, in 33 licensed athletes, changes concerning 35 metabolites. Results: We observed significant changes in many metabolites, including increased acetyl-carnitine and taurine concentrations (false discovery rate–corrected paired t-test P value 1.63 × 10–13, and P value 5.021 × 10-12, re- spectively) and decreased carnitine and proline concentrations (P value 6.33 × 10–10, and P value 1.21 × 10–9, re- spectively). Metabolic responses to trail running were largely independent of sex but were influenced by the level of training, with runners with a higher level showing resistance to exercise-induced changes in taurine, 1-methyl histidine, acetyl-carnitine, and hypoxanthine concentrations. Performance (measured as race time) was inversely correlated with changes in specific metabolites (including taurine, serotonin, and hypoxanthine) and directly correlated with increases in glutathione. Conclusions: Our findings demonstrate the usefulness of metabolomics studies for analyzing exercise-induced physiological changes and show individual differences associated with the level of training and performance. ; This work was supported by the Generalitat de Catalunya, Agency for Management of University and Research Grants [2017SGR696]; by the Spanish Ministry of Economy and Competitiveness, Institute of Health Carlos III [PI17-00134 and PI20-00155]; and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1440-2440 |
| العلاقة: | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099200-B-I00/ES/NEUROLIPIDOMICA DEL ENVEJECIMIENTO CEREBRAL HUMANO/; Reproducció del document publicat a https://doi.org/10.1016/j.jsams.2021.12.006Test; Journal of Science and Medicine in Sport, 2022, vol. 25, num. 5, p. 425-431; http://hdl.handle.net/10459.1/72965Test; https://doi.org/10.1016/j.jsams.2021.12.006Test |
| DOI: | 10.1016/j.jsams.2021.12.006 |
| الإتاحة: | https://doi.org/10.1016/j.jsams.2021.12.006Test http://hdl.handle.net/10459.1/72965Test |
| حقوق: | cc-by-nc-nd (c) Puigarnau et al., 2021 ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C10B2927 |
| قاعدة البيانات: | BASE |
| تدمد: | 14402440 |
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| DOI: | 10.1016/j.jsams.2021.12.006 |