التفاصيل البيبلوغرافية
| العنوان: |
A Human Vascular Injury‐on‐a‐Chip Model of Hemostasis |
| المؤلفون: |
Poventud‐Fuentes, Izmarie, Kwon, Keon Woo, Seo, Jeongyun, Tomaiuolo, Maurizio, Stalker, Timothy J., Brass, Lawrence F., Huh, Dongeun |
| المساهمون: |
National Institutes of Health, National Science Foundation, Korea Institute for Advancement of Technology, National Research Foundation of Korea, Paul G. Allen Family Foundation |
| المصدر: |
Small ; volume 17, issue 15 ; ISSN 1613-6810 1613-6829 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2020 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Hemostasis is an innate protective mechanism that plays a central role in maintaining the homeostasis of the vascular system during vascular injury. Studying this essential physiological process is often challenged by the difficulty of modeling and probing the complex dynamics of hemostatic responses in the native context of human blood vessels. To address this major challenge, this paper describes a microengineering approach for in vitro modeling of hemostasis. This microphysiological model replicates the living endothelium, multilayered microarchitecture, and procoagulant activity of human blood vessels, and is also equipped with a microneedle that is actuated with spatial precision to simulate penetrating vascular injuries. The system recapitulates key features of the hemostatic response to acute vascular injury as observed in vivo, including i) thrombin‐driven accumulation of platelets and fibrin, ii) formation of a platelet‐ and fibrin‐rich hemostatic plug that halts blood loss, and iii) matrix deformation driven by platelet contraction for wound closure. Moreover, the potential use of this model for drug testing applications is demonstrated by evaluating the effects of anticoagulants and antiplatelet agents that are in current clinical use. The vascular injury‐on‐a‐chip may serve as an enabling platform for preclinical investigation of hematological disorders and emerging therapeutic approaches against them. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/smll.202004889 |
| الإتاحة: |
https://doi.org/10.1002/smll.202004889Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#amTest ; http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.C0F5CFF9 |
| قاعدة البيانات: |
BASE |
