دورية أكاديمية
Immunohistochemical Glucagon-like Peptide-1 Receptor Expression in Human Insulinomas
| العنوان: | Immunohistochemical Glucagon-like Peptide-1 Receptor Expression in Human Insulinomas |
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| المؤلفون: | Vesterinen, Tiina, Peltola, Elina, Leijon, Helena, Hannula, Päivi, Huhtala, Heini, Mäkinen, Markus J., Nieminen, Lasse, Pirinen, Elina, Rönty, Mikko, Söderström, Mirva, Jaatinen, Pia, Arola, Johanna |
| المساهمون: | Tampere University, Department of Internal medicine, Clinical Medicine, Health Sciences, Department of Pathology, Seinäjoki Central Hospital |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | 3121 Internal medicine, 3111 Biomedicine, 3141 Health care science |
| الوصف: | Insulinomas are rare functional pancreatic neuroendocrine tumours, which metastasize in 10% of cases. As predicting the prognosis can be challenging, there is a need for the determination of clinicopathological factors associated with metastatic potential. The aim of this study is to evaluate the glucagon-like peptide-1 receptor (GLP-1R) expression in insulinomas and to analyse its association with clinicopathological features and patient outcome. This retrospective study involves pancreatic tumour tissue samples from fifty-two insulinoma patients. After histological re-evaluation, formalin-fixed paraffin-embedded tissue samples were processed into tissue microarrays and stained immunohistochemically with a monoclonal GLP-1R antibody. Forty-eight of the forty-nine (98%) non-metastatic tumours expressed GLP-1R, while one non-metastatic, multiple endocrine neoplasia type 1 (MEN1)-related tumour and all three of the metastatic tumours lacked GLP-1R expression. The lack of GLP-1R expression was associated with impaired overall survival, larger tumour diameter, higher Ki-67 PI and weaker insulin staining. Somatostatin receptor 1–5 expression did not differ between GLP-1R-positive and GLP-1R-negative insulinomas. In conclusion, the lack of GLP-1R expression is associated with metastatic disease and impaired survival in insulinoma patients. Thus, GLP-1R expression could be a useful biomarker in estimating the metastatic potential of the tumour and the prognosis of surgically treated patients. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | fulltext |
| اللغة: | English |
| تدمد: | 1661-6596 |
| العلاقة: | 15164; 20; 24; ORCID: /0000-0003-3172-9331/work/146639071; ORCID: /0000-0002-8693-3498/work/146640195; https://trepo.tuni.fi/handle/10024/152640Test; URN:NBN:fi:tuni-202311149627 |
| DOI: | 10.3390/ijms242015164 |
| الإتاحة: | https://doi.org/10.3390/ijms242015164Test https://trepo.tuni.fi/handle/10024/152640Test |
| حقوق: | cc by 4.0 ; openAccess |
| رقم الانضمام: | edsbas.C0C21711 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16616596 |
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| DOI: | 10.3390/ijms242015164 |