دورية أكاديمية
Degradation Mechanisms of Six Typical Glucosidic Bonds of Disaccharides Induced by Free Radicals
| العنوان: | Degradation Mechanisms of Six Typical Glucosidic Bonds of Disaccharides Induced by Free Radicals |
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| المؤلفون: | Biyang Zhu, Cong Ma, Lijun You |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Medicine, Developmental Biology, Cancer, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, trehalose ≈ isomaltose, sucrose ≈ maltose, quantum chemical calculations, cellobiose ≈ lactose, based alkoxyl radicals, alkoxyl radicals ranked, uv )/ h, order kinetic constants, 2 , published degradation mechanisms, free radicals, superoxide radical, study helps, study aimed, still limited, results showed, reaction pathways, radiation intensity, kinetically unfavorable, hydroxyl radical, homolytic scissions |
| الوصف: | Increasing hydrogen peroxide (H 2 O 2 )-based systems have been developed to degrade various polysaccharides due to the presence of highly reactive free radicals, but published degradation mechanisms are still limited. Therefore, this study aimed to clarify the degradation mechanism of six typical glucosidic bonds from different disaccharides in an ultraviolet (UV)/H 2 O 2 system. The results showed that the H 2 O 2 concentration, disaccharide concentration, and radiation intensity were important factors affecting pseudo-first-order kinetic constants. Hydroxyl radical, superoxide radical, and UV alone contributed 58.37, 18.52, and 19.17% to degradation, respectively. The apparent degradation rates ranked in the order of cellobiose ≈ lactose > trehalose ≈ isomaltose > turanose > sucrose ≈ maltose. The reaction pathways were then deduced after identifying their degradation products. According to quantum chemical calculations, the cleavage of α-glycosidic bonds was more kinetically unfavorable than that of β-glycosidic bonds. Additionally, the order of apparent degradation rates depended on the energy barriers for the formation of disaccharide-based alkoxyl radicals. Moreover, energy barriers for homolytic scissions of glucosidic C 1 –O or C 7 –O sites of these alkoxyl radicals ranked in the sequence: α-(1 → 2) ≈ α-(1 → 3) < α-(1 → 4) < β-(1 → 4) < α-(1 → 6) < α-(1 → 1) glucosidic bonds. This study helps to explain the mechanisms of carbohydrate degradation by free radicals. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/Degradation_Mechanisms_of_Six_Typical_Glucosidic_Bonds_of_Disaccharides_Induced_by_Free_Radicals/25300952Test |
| DOI: | 10.1021/acs.jafc.3c09344.s001 |
| الإتاحة: | https://doi.org/10.1021/acs.jafc.3c09344.s001Test https://figshare.com/articles/journal_contribution/Degradation_Mechanisms_of_Six_Typical_Glucosidic_Bonds_of_Disaccharides_Induced_by_Free_Radicals/25300952Test |
| حقوق: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.C0C15208 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.jafc.3c09344.s001 |
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