دورية أكاديمية
Quality of life in men with Klinefelter syndrome: a multicentre study
| العنوان: | Quality of life in men with Klinefelter syndrome: a multicentre study |
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| المؤلفون: | Franik, Sebastian, Fleischer, Kathrin, Kortmann, Barbara, Stikkelbroeck, Nike M, D’Hauwers, Kathleen, Bouvattier, Claire, Slowikowska-Hilczer, Jolanta, Grunenwald, Solange, van de Grift, Tim, Cartault, Audrey, Richter-Unruh, Annette, Reisch, Nicole, Thyen, Ute, IntHout, Joanna, Claahsen-van der Grinten, Hedi L, , |
| المصدر: | Endocrine Connections ; volume 12, issue 10 ; ISSN 2049-3614 |
| بيانات النشر: | Bioscientifica |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Endocrinology, Endocrinology, Diabetes and Metabolism, Internal Medicine |
| الوصف: | Background Klinefelter syndrome (KS) is associated with an increased risk of lower socioeconomic status and a higher risk for morbidity and mortality, which may have a significant impact on quality of life (QOL). The objective of this study is to investigate QOL in a large European cohort of men with KS. Design Cross-sectional multicentre study. Methods Two-hundred-eighteen men with KS were recruited from 14 clinical study centres in 6 European countries which participated in the European dsd-LIFE study. Male normative data from a healthy and a psychiatric reference population were used for comparison. The validated World Health Organization (WHO) QOL (WHOQOL)-BREF questionnaire was used to investigate five main domains of quality of life (WHOQOL): global, physical, psychological, environment, and social. Results The QOL physical domain score was lower for men with KS compared to the healthy reference population (KS: 66.9; s.d. 19.4, n = 193; healthy reference population: 76.5; s.d. 16.2, n = 1324, P < 0.001) but higher compared to the psychiatric reference population (54.6; s.d. 20.6; n = 77, P < 0.001). The WHOQOL-psychological domain score was lower for men with KS compared to the healthy reference population (KS: 63.6; s.d. 17.8, n = 193; healthy reference population: 67.8; s.d. 15.6, n = 1324, P < 0.05) but higher compared to the psychiatric reference population (45.9; s.d. 26.0), n = 77, P < 0.001). The social domain score on the WHOQOL questionnaire was found to be lower in men with Klinefelter syndrome (KS) compared to the healthy reference population (KS: 60.0; s.d. 21.6, n = 193; healthy reference population: 68.2; s.d. 13.8, n = 1324, P < 0.001). However, this score was similar to that of the psychiatric reference population (61.0; s.d. 17.0, n = 77, P = 0.5). The WHO environment domain score of men with KS (70.0; s.d. 15.0, n = 193) was similar to the healthy reference population (70.5; s.d. 20.7, n = 1324) but higher compared to the psychiatric reference population (61.9; s.d. 20.8, n ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.1530/ec-23-0111 |
| الإتاحة: | https://doi.org/10.1530/ec-23-0111Test https://ec.bioscientifica.com/view/journals/ec/12/10/EC-23-0111.xmlTest |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.C09B80CE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1530/ec-23-0111 |
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