دورية أكاديمية
Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages
| العنوان: | Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages |
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| المؤلفون: | Sierra, Jose Rafael, Corso, Simona, Caione, Luisa, Cepero, Virna, Conrotto, Paolo, Cignetti, Alessandro, Piacibello, Wanda, Kumanogoh, Atsushi, Kikutani, Hitoshi, Comoglio, Paolo Maria, Tamagnone, Luca, Giordano, Silvia |
| المصدر: | The Journal of Experimental Medicine ; volume 205, issue 7, page 1673-1685 ; ISSN 1540-9538 0022-1007 |
| بيانات النشر: | Rockefeller University Press |
| سنة النشر: | 2008 |
| الوصف: | Increased evidence suggests that cancer-associated inflammation supports tumor growth and progression. We have previously shown that semaphorin 4D (Sema4D), a ligand produced by different cell types, is a proangiogenic molecule that acts by binding to its receptor, plexin B1, expressed on endothelial cells (Conrotto, P., D. Valdembri, S. Corso, G. Serini, L. Tamagnone, P.M. Comoglio, F. Bussolino, and S. Giordano. 2005. Blood. 105:4321–4329). The present work highlights the role of Sema4D produced by the tumor microenvironment on neoplastic angiogenesis. We show that in an environment lacking Sema4D, the ability of cancer cells to generate tumor masses and metastases is severely impaired. This condition can be explained by a defective vascularization inside the tumor. We demonstrate that tumor-associated macrophages (TAMs) are the main cells producing Sema4D within the tumor stroma and that their ability to produce Sema4D is critical for tumor angiogenesis and vessel maturation. This study helps to explain the protumoral role of inflammatory cells of the tumor stroma and leads to the identification of an angiogenic molecule that might be a novel therapeutic target. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1084/jem.20072602 |
| الإتاحة: | https://doi.org/10.1084/jem.20072602Test https://rupress.org/jem/article-pdf/205/7/1673/1900417/jem_20072602.pdfTest |
| رقم الانضمام: | edsbas.C097AF8F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1084/jem.20072602 |
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