دورية أكاديمية
Endogenous Asymmetric Dimethylarginine Pathway in High Altitude Adapted Yaks
| العنوان: | Endogenous Asymmetric Dimethylarginine Pathway in High Altitude Adapted Yaks |
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| المؤلفون: | Shiro Mizuno, Takeshi Ishizaki, Hirohisa Toga, Akio Sakai, Jainagul Isakova, Elnura Taalaibekova, Zamirbek Baiserkeev, Baktybek Kojonazarov, Almaz Aldashev |
| المصدر: | BioMed Research International, Vol 2015 (2015) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2015 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine |
| الوصف: | Hypoxia-induced and high altitude pulmonary hypertension are a major problem in the mountain areas of the world. The asymmetric methylarginines (ADMA) inhibit nitric oxide (NO) synthesis by competing with L-arginine, and high levels of plasma ADMA predict adverse outcomes in pulmonary hypertension. However, little is known about the regulation of the ADMA-NO pathway in animals adapted to high altitudes. We measured the plasma ADMA concentration, endothelial NO synthase (eNOS), dimethylarginine dimethylaminohydrolases (DDAH) protein expression, and DDAH activities in the lungs from yaks. Although the yaks are hypoxemic, cardiac function and pulmonary arterial pressures are almost normal, and we found decreased DDAH expression and activity in association with reduced plasma ADMA concentrations. The eNOS expression was significantly higher in yaks. These results indicate that augmented endogenous NO activity in yaks through the ADMA-DDAH pathway and eNOS upregulation account for the low pulmonary vascular tone observed in high altitude adapted yaks. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2314-6133 2314-6141 |
| العلاقة: | http://dx.doi.org/10.1155/2015/196904Test; https://doaj.org/toc/2314-6133Test; https://doaj.org/toc/2314-6141Test; https://doaj.org/article/e7b788d3ed4e4ad492ea88b96a02040eTest |
| DOI: | 10.1155/2015/196904 |
| الإتاحة: | https://doi.org/10.1155/2015/196904Test https://doaj.org/article/e7b788d3ed4e4ad492ea88b96a02040eTest |
| رقم الانضمام: | edsbas.C04198FE |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23146133 23146141 |
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| DOI: | 10.1155/2015/196904 |