دورية أكاديمية
Anticipated basal insulin reduction to prevent exercise-induced hypoglycemia in adults and adolescents living with type 1 diabetes.
| العنوان: | Anticipated basal insulin reduction to prevent exercise-induced hypoglycemia in adults and adolescents living with type 1 diabetes. |
|---|---|
| المؤلفون: | Tagougui, Semah, Legault, Laurent, Heyman, Elsa, Messier, Virginie, Suppere, Corinne, Potter, Kathryn J., Pigny, Pascal, Berthoin, Serge, Taleb, Nadine, Rabasa-Lhoret, Rémi |
| المساهمون: | Université de Lille, Univ. Artois, Univ. Littoral Côte d’Opale, Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 URePSSS, McGill University = Université McGill Montréal, Canada, Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369, Institut de Recherches Cliniques de Montréal IRCM, Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277 |
| بيانات النشر: | Mary Ann Liebert |
| سنة النشر: | 2023 |
| المجموعة: | LillOA (Lille Open Archive - Université de Lille) |
| مصطلحات موضوعية: | Anticipated basal insulin reduction, Exercise-induced hypoglycemia, Insulin pump, Adolescent |
| الوصف: | Objective: We investigated the effect of two key timings for basal insulin rate reduction on exercise-induced glucose changes and explored the association between circulating insulin concentrations and muscle vasoreactivity. Research Design and Methods: Twenty adults and adolescents performed 60-min exercise sessions (ergocycle) at 60% VO2peak, 240 min after a standardized lunch. In a randomized order, we compared an 80% basal insulin reduction applied 40 min (T-40) or 90 min (T-90) before exercise onset. Near-infrared spectroscopy was used to investigate muscle hemodynamics at vastus lateralis. Glucose and insulin plasma concentrations were measured. Results: Reduction in plasma glucose (PG) level during exercise was attenuated during T-90 versus T-40 strategy (−0.89 ± 1.89 mmol/L vs. −2.17 ± 2.49 mmol/L, respectively; P = 0.09). Linear mixed model analysis showed that PG dropped by an additional 0.01 mM per minute in T-40 versus T-90 (time × strategy interaction, P < 0.05). The absolute number of hypoglycemic events was not different between the two strategies, but they occurred later with T-90. Free insulin tends to decrease more during the pre-exercise period in the T-90 strategy (P = 0.08). Although local muscle vasodilatation (ΔTHb) was comparable between the two strategies, we found that PG dropped more in cases of higher exercise-induced skeletal muscle vasodilatation (ΔTHb × time interaction P < 0.005, e: −0.0086 mM/min and additional mM of ΔTHb). Conclusion: T-90 timing reduced exercise-induced drop in PG and delayed the occurrence of hypoglycemic episodes compared with T-40 timing without a significant reduction in the number of events requiring treatment. ; 24;5 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/octet-stream |
| اللغة: | English |
| العلاقة: | Diabetes Technology and Therapeutics; Diabetes Technol Ther; http://hdl.handle.net/20.500.12210/82202Test |
| الإتاحة: | https://doi.org/20.500.12210/82202Test https://hdl.handle.net/20.500.12210/82202Test |
| رقم الانضمام: | edsbas.C01765C8 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |