التفاصيل البيبلوغرافية
| العنوان: |
Association between plasminogen activator inhibitor‐1 in young adulthood and nonalcoholic fatty liver disease in midlife: CARDIA |
| المؤلفون: |
Campbell, Patrick T, VanWagner, Lisa B, Colangelo, Laura A, Lewis, Cora E, Henkel, Anne, Ajmera, Veeral H, Lloyd‐Jones, Donald M, Vaughan, Douglas E, Khan, Sadiya S |
| المصدر: |
Liver International, vol 40, iss 5 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2020 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Clinical Research, Prevention, Chronic Liver Disease and Cirrhosis, Liver Disease, Adult, Cross-Sectional Studies, Female, Humans, Male, Non-alcoholic Fatty Liver Disease, Obesity, Plasminogen Activator Inhibitor 1, Risk Factors, Young Adult, computed tomography, hepatic, metabolic syndrome, steatosis, Gastroenterology & Hepatology |
| الوقت: |
1111 - 1120 |
| الوصف: |
BackgroundPrior studies have demonstrated a cross-sectional association between elevated plasminogen activator inhibitor-1 (PAI-1) levels and nonalcoholic fatty liver disease (NAFLD). However, there are no prospective longitudinal assessments of the association between PAI-1 and NAFLD. We aimed to describe the association between PAI-1 levels in early adulthood with NAFLD in midlife.MethodsAmong the 5115 participants in the coronary artery risk development in young adults (CARDIA) study, participants were randomly selected from a subset that was free of obesity, diabetes and hypertension at the 1992-1993 exam and attended the 2005-2006 exam (n=996). A subset of participants (n=896) also had CT liver fat measured (2010-2011). Participants with secondary causes of steatosis were excluded (n=87). NAFLD was defined as liver attenuation ≤51 Hounsfield units. Logistic regression models assessed the association between PAI-1 and NAFLD.ResultsOf 809 participants, 53% were female, 37% black with a mean age of 32years. Median PAI-1 level at 1st assessment (1992-1993) was 23.4ng/mL among participants with NAFLD vs 11.9ng/mL among those without NAFLD (P<.0001). Median PAI-1 level at 2nd assessment (2005-2006) was 55.6ng/mL among participants with NAFLD vs 19.5ng/mL among those without NAFLD (P<.0001). Higher PAI-1 levels were independently associated with NAFLD (1st assessment adjusted OR [AOR] 2.16 per 1 standard deviation higher log(PAI-1) level (95% confidence interval [CI] 1.63-2.85); 2nd assessment AOR 2.71 (95% CI 2.03-3.61)).ConclusionsPlasma PAI-1 levels in young adulthood were independently associated with NAFLD in midlife. Further studies may indicate whether PAI-1 plays a role in NAFLD pathophysiology. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt3v16n0p8; https://escholarship.org/uc/item/3v16n0p8Test |
| الإتاحة: |
https://escholarship.org/uc/item/3v16n0p8Test |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.BFE4EA8A |
| قاعدة البيانات: |
BASE |
