مؤتمر
Transgenerational epigenetics in quail ; Transgenerational epigenetics in quail: whole genome DNA methylation analysis
| العنوان: | Transgenerational epigenetics in quail ; Transgenerational epigenetics in quail: whole genome DNA methylation analysis |
|---|---|
| المؤلفون: | Cerutti, Chloé, Leroux, Sophie, Terzian, Paul, Lledo, Joanna, Gourichon, David, Serre, Rémy-Félix, Vandecasteele, Céline, Klopp, Christophe, C., Iampietro, Carole, Gaspin, Christine, Milan, Denis, Donnadieu, Cécile, Pitel, Frederique, Devailly, Guillaume |
| المساهمون: | Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de Mathématiques et Informatique Appliquées de Toulouse (MIAT INRAE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génome et Transcriptome - Plateforme Génomique ( GeT-PlaGe), Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées Auzeville (GENOTOUL), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité Expérimentale Avicole de Tours (UE PEAT), Région Occitanie - FEDER, SeqOccIn |
| المصدر: | ECCB2022 - 21st European Conference on Computational Biology ; https://hal.inrae.fr/hal-03935584Test ; ECCB2022 - 21st European Conference on Computational Biology, Sep 2022, Sitges, Spain |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2022 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| جغرافية الموضوع: | Sitges, Spain |
| الوصف: | International audience ; The influence of the prenatal environment on the adult phenotype development is partially mediated by epigenetics phenomena. One study highlighted significant effects of the in-ovo injection of endocrine disruptors or DNA methyltransferase inhibitor on quail development, significantly reducing their weight [1]. Recently, an increasing number of studies highlighted the transmission of epigenetics marks between generations following an environmental exposure. However, there is much debate about their acquired transmission beyond the exposed individuals. Recent studies revealed that non-genetics inheritance was probably present in avian species. In one of them [2], fertilized eggs were divided into two groups: one group injected with an endocrine disruptor, Genistein, and a non-injected control group. After three generations without any other injection, several traits were impacted by the ancestor treatment such as the reproduction and the behavior. This pilot study highlighted the potential existence of transgenerational transmission of environmental effects in quails. To better understand the transgenerational transmission of these environmental effects, DNA methylation data are available from blood samples from the third generation (WGBS and ONT). To analyse the DNA methylation state, we developed a bioinformatics pipeline in order to detect differential methylated cytosines (DMCs) affected by these transgenerational phenomena. We detected thousands of DMCs between both groups. In addition to these analyses, these data allowed us to perform a comparative analysis between the WGBS and ONT sequencing technologies. |
| نوع الوثيقة: | conference object still image |
| اللغة: | English |
| العلاقة: | hal-03935584; https://hal.inrae.fr/hal-03935584Test; https://hal.inrae.fr/hal-03935584/documentTest; https://hal.inrae.fr/hal-03935584/file/poster_ECCB_2022_CERUTTI_Chloe_final.pdfTest |
| الإتاحة: | https://hal.inrae.fr/hal-03935584Test https://hal.inrae.fr/hal-03935584/documentTest https://hal.inrae.fr/hal-03935584/file/poster_ECCB_2022_CERUTTI_Chloe_final.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.BFBBE996 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |