دورية أكاديمية
Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer
| العنوان: | Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer |
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| المؤلفون: | Cords, Lena, Engler, Stefanie, Haberecker, Martina, Rüschoff, Jan Hendrik, Moch, Holger, de Souza, Natalie, Bodenmiller, Bernd |
| المصدر: | Cords, Lena; Engler, Stefanie; Haberecker, Martina; Rüschoff, Jan Hendrik; Moch, Holger; de Souza, Natalie; Bodenmiller, Bernd (2024). Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer. Cancer Cell, 42(3):396-412.e5. |
| بيانات النشر: | Cell Press (Elsevier) |
| سنة النشر: | 2024 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Department of Quantitative Biomedicine, Institute of Pathology and Molecular Pathology, 610 Medicine & health |
| الوصف: | Despite advances in treatment, lung cancer survival rates remain low. A better understanding of the cellular heterogeneity and interplay of cancer-associated fibroblasts (CAFs) within the tumor microenvironment will support the development of personalized therapies. We report a spatially resolved single-cell imaging mass cytometry (IMC) analysis of CAFs in a non-small cell lung cancer cohort of 1,070 patients. We identify four prognostic patient groups based on 11 CAF phenotypes with distinct spatial distributions and show that CAFs are independent prognostic factors for patient survival. The presence of tumor-like CAFs is strongly correlated with poor prognosis. In contrast, inflammatory CAFs and interferon-response CAFs are associated with inflamed tumor microenvironments and higher patient survival. High density of matrix CAFs is correlated with low immune infiltration and is negatively correlated with patient survival. In summary, our data identify phenotypic and spatial features of CAFs that are associated with patient outcome in NSCLC. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1535-6108 |
| العلاقة: | https://www.zora.uzh.ch/id/eprint/256986/8/Cords_et_al_lung.pdfTest; info:pmid/38242124; urn:issn:1535-6108 |
| DOI: | 10.5167/uzh-256986 |
| DOI: | 10.1016/j.ccell.2023.12.021 |
| الإتاحة: | https://doi.org/10.5167/uzh-25698610.1016/j.ccell.2023.12.021Test https://www.zora.uzh.ch/id/eprint/256986Test/ https://www.zora.uzh.ch/id/eprint/256986/8/Cords_et_al_lung.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess ; Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.BFAD02A4 |
| قاعدة البيانات: | BASE |
| تدمد: | 15356108 |
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| DOI: | 10.5167/uzh-256986 |