دورية أكاديمية
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
| العنوان: | Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity |
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| المؤلفون: | Cyrta J., Augspach A., De Filippo M. R., Prandi D., Thienger P., Benelli M., Cooley V., Bareja R., Wilkes D., Chae S. -S., Cavaliere P., Dephoure N., Uldry A. -C., Lagache S. B., Roma L., Cohen S., Jaquet M., Brandt L. P., Alshalalfa M., Puca L., Sboner A., Feng F., Wang S., Beltran H., Lotan T., Spahn M., Kruithof-de Julio M., Chen Y., Ballman K. V., Demichelis F., Piscuoglio S., Rubin M. A. |
| المساهمون: | Cyrta, J., Augspach, A., De Filippo, M. R., Prandi, D., Thienger, P., Benelli, M., Cooley, V., Bareja, R., Wilkes, D., Chae, S. -S., Cavaliere, P., Dephoure, N., Uldry, A. -C., Lagache, S. B., Roma, L., Cohen, S., Jaquet, M., Brandt, L. P., Alshalalfa, M., Puca, L., Sboner, A., Feng, F., Wang, S., Beltran, H., Lotan, T., Spahn, M., Kruithof-de Julio, M., Chen, Y., Ballman, K. V., Demichelis, F., Piscuoglio, S., Rubin, M. A. |
| سنة النشر: | 2020 |
| المجموعة: | Università degli Studi di Trento: CINECA IRIS |
| مصطلحات موضوعية: | Adenocarcinoma, Cell Line, Tumor, Chromosomal Proteins, Non-Histone, Cohort Studie, DNA Helicase, Gene Expression Regulation, Neoplastic, Human, Kaplan-Meier Estimate, Male, Models, Biological, Neoplasm Invasivene, Neoplasm Protein, Neuroendocrine Tumor, Nuclear Protein, Prostatic Neoplasm, Protein Subunit, Transcription Factor, Transcriptome, Cell Lineage, Cell Plasticity |
| الوصف: | Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance observed in around 10–20% of these patients is lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine prostate cancer (NEPC) phenotype. Here, we investigate the role of the mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complex in NEPC. Using large patient datasets, patient-derived organoids and cancer cell lines, we identify mSWI/SNF subunits that are deregulated in NEPC and demonstrate that SMARCA4 (BRG1) overexpression is associated with aggressive disease. We also show that SWI/SNF complexes interact with different lineage-specific factors in NEPC compared to prostate adenocarcinoma. These data point to a role for mSWI/SNF complexes in therapy-related lineage plasticity, which may also be relevant for other solid tumors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33144576; info:eu-repo/semantics/altIdentifier/wos/WOS:000591843300004; volume:11; issue:1; firstpage:5549; journal:NATURE COMMUNICATIONS; http://hdl.handle.net/11572/312485Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85094950357 |
| DOI: | 10.1038/s41467-020-19328-1 |
| الإتاحة: | https://doi.org/10.1038/s41467-020-19328-1Test http://hdl.handle.net/11572/312485Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.BF6871D1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-020-19328-1 |
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