دورية أكاديمية
Relative wash-in rate in dynamic contrast-enhanced magnetic resonance imaging as a new prognostic biomarker for event-free survival in 82 patients with osteosarcoma : a multicenter study
| العنوان: | Relative wash-in rate in dynamic contrast-enhanced magnetic resonance imaging as a new prognostic biomarker for event-free survival in 82 patients with osteosarcoma : a multicenter study |
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| المؤلفون: | Kalisvaart, Gijsbert M., Evenhuis, Richard E., Grootjans, Willem, Van Den Berghe, Thomas, Callens, Martijn, Bovée, Judith V. M. G., Creytens, David, Gelderblom, Hans, Speetjens, Frank M., Lapeire, Lore, Sys, Gwen, Fiocco, Marta, Verstraete, Koenraad, van de Sande, Michiel A. J., Bloem, Johan L. |
| المصدر: | CANCERS ; ISSN: 2072-6694 |
| سنة النشر: | 2024 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Medicine and Health Sciences, osteosarcoma, neoadjuvant chemotherapy, response monitoring, histological response, dynamic contrast-enhanced MRI, survival outcome, OSTEOGENIC-SARCOMA, PEDIATRIC-PATIENTS, CHEMOTHERAPY, OUTCOMES, MRI |
| الوصف: | Background: The decreased perfusion of osteosarcoma in dynamic contrast-enhanced (DCE) MRI, reflecting a good histological response to neoadjuvant chemotherapy, has been described. Purpose: In this study, we aim to explore the potential of the relative wash-in rate as a prognostic factor for event-free survival (EFS). Methods: Skeletal high-grade osteosarcoma patients, treated in two tertiary referral centers between 2005 and 2022, were retrospectively included. The relative wash-in rate (rWIR) was determined with DCE-MRI before, after, or during the second cycle of chemotherapy (pre-resection). A previously determined cut-off was used to categorize patients, where rWIR < 2.3 was considered poor and rWIR ≥ 2.3 a good radiological response. EFS was defined as the time from resection to the first event: local recurrence, new metastases, or tumor-related death. EFS was estimated using Kaplan–Meier’s methodology. Multivariate Cox proportional hazard model was used to estimate the effect of histological response and rWIR on EFS, adjusted for traditional prognostic factors. Results: Eighty-two patients (median age: 17 years; IQR: 14–28) were included. The median follow-up duration was 11.8 years (95% CI: 11.0–12.7). During follow-up, 33 events occurred. Poor histological response was not significantly associated with EFS (HR: 1.8; 95% CI: 0.9–3.8), whereas a poor radiological response was associated with a worse EFS (HR: 2.4; 95% CI: 1.1–5.0). In a subpopulation without initial metastases, the binary assessment of rWIR approached statistical significance (HR: 2.3; 95% CI: 1.0–5.2), whereas its continuous evaluation demonstrated a significant association between higher rWIR and improved EFS (HR: 0.7; 95% CI: 0.5–0.9), underlining the effect of response to chemotherapy. The 2- and 5-year EFS for patients with a rWIR ≥ 2.3 were 85% and 75% versus 55% and 50% for patients with a rWIR < 2.3. Conclusion: The predicted poor chemo response with MRI (rWIR < 2.3) is associated with shorter EFS even when adjusted for ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://biblio.ugent.be/publication/01HYJ3TWGWT5AXSFPSKNKQN61ETest; http://hdl.handle.net/1854/LU-01HYJ3TWGWT5AXSFPSKNKQN61ETest; http://doi.org/10.3390/cancers16111954Test; https://biblio.ugent.be/publication/01HYJ3TWGWT5AXSFPSKNKQN61E/file/01HYJ44TFE9W2N9CFHRTZSSAKRTest |
| DOI: | 10.3390/cancers16111954 |
| الإتاحة: | https://doi.org/10.3390/cancers16111954Test https://biblio.ugent.be/publication/01HYJ3TWGWT5AXSFPSKNKQN61ETest http://hdl.handle.net/1854/LU-01HYJ3TWGWT5AXSFPSKNKQN61ETest https://biblio.ugent.be/publication/01HYJ3TWGWT5AXSFPSKNKQN61E/file/01HYJ44TFE9W2N9CFHRTZSSAKRTest |
| حقوق: | Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.BF5FAF7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers16111954 |
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