دورية أكاديمية
Multiparametric investigation of non functionalized-AGuIX nanoparticles in 3D human airway epithelium models demonstrates preferential targeting of tumor cells
| العنوان: | Multiparametric investigation of non functionalized-AGuIX nanoparticles in 3D human airway epithelium models demonstrates preferential targeting of tumor cells |
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| المؤلفون: | Sancey, Lucie, Sabido, Odile, He, Zhiguo, Rossetti, Fabien, Guignandon, Alain, Bin, Valérie, Coll, Jean-Luc, Cottier, Michèle, Lux, François, Tillement, Olivier, Constant, Samuel, Mas, Christophe, Boudard, Delphine |
| المساهمون: | Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biologie, Ingénierie et Imagerie pour l'Ophtalmologie (BIIO), Université Jean Monnet - Saint-Étienne (UJM), iLM - Formation, élaboration de nanomatériaux et cristaux (iLM - FENNEC), Institut Lumière Matière Villeurbanne (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), NH TherAguix SA Meylan, Epithelix SARL Geneva, Switzerland, Université de Genève = University of Geneva (UNIGE), OncoTheis SARL Geneva, Switzerland, Service de Cytologie - Histologie Rénale - Embryologie CHU Saint-Etienne (UF 6725 - UF 6726), Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM) |
| المصدر: | ISSN: 1477-3155 ; Journal of Nanobiotechnology ; https://inserm.hal.science/inserm-02941434Test ; Journal of Nanobiotechnology, 2020, 18 (1), pp.129. ⟨10.1186/s12951-020-00683-6⟩. |
| بيانات النشر: | HAL CCSD BioMed Central |
| سنة النشر: | 2020 |
| المجموعة: | Université Jean Monnet – Saint-Etienne: HAL |
| مصطلحات موضوعية: | AGuIX ® nanoparticles, 3D human healthy and tumor airway models, Nanoparticle's toxicity, Nanoparticle's uptake, Tumor targeting, [SDV]Life Sciences [q-bio], [SDV.BIO]Life Sciences [q-bio]/Biotechnology |
| الوصف: | International audience ; Liquid deposit mimicking surface aerosolization in the airway is a promising strategy for targeting bronchopulmonary tumors with reduced doses of nanoparticle (NPs). In mimicking and studying such delivery approaches, the use of human in vitro 3D culture models can bridge the gap between 2D cell culture and small animal investigations. Here, we exposed airway epithelia to liquid-apical gadolinium-based AGuIX ® NPs in order to determine their safety profile. We used a multiparametric methodology to investigate the NP's distribution over time in both healthy and tumor-bearing 3D models. AGuIX ® NPs were able to target tumor cells in the absence of specific surface functionalization, without evidence of toxicity. Finally, we validated the therapeutic potential of this hybrid theranostic AGuIX ® NPs upon radiation exposure in this model. In conclusion, 3D cell cultures can efficiently mimic the normal and tumor-bearing airway epitheliums, providing an ethical and accessible model for the investigation of nebulized NPs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32912214; inserm-02941434; https://inserm.hal.science/inserm-02941434Test; https://inserm.hal.science/inserm-02941434/documentTest; https://inserm.hal.science/inserm-02941434/file/80-2020-Mucil_OncoCilAir.pdfTest; PUBMED: 32912214 |
| DOI: | 10.1186/s12951-020-00683-6 |
| الإتاحة: | https://doi.org/10.1186/s12951-020-00683-6Test https://inserm.hal.science/inserm-02941434Test https://inserm.hal.science/inserm-02941434/documentTest https://inserm.hal.science/inserm-02941434/file/80-2020-Mucil_OncoCilAir.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.BF393ABB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12951-020-00683-6 |
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