دورية أكاديمية
GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report form the COGENT consortium
العنوان: | GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report form the COGENT consortium |
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المؤلفون: | Trampush, Joey W., Yang, M.L.Z., Yu, Jin, Knowles, Emma, Davies, Gail, Liewald, David C.M., Starr, John M., Djurovic, Srdjan, Melle, Ingrid, Sundet, Kjetil Søren, Christoforou, Andrea, Reinvang, Ivar, DeRosse, Pamela, Lundervold, Astri, Steen, Vidar Martin, Espeseth, Thomas, Räikkönen, Katri, Widén, Elisabeth, Palotie, Aarno, Eriksson, Johan Gunnar, Giegling, Ina, Konte, Bettina, Roussos, Panos, Giakoumaki, Stella, Burdick, Katherine E., Payton, Antony, Ollier, William E.R., Horan, Michael Arthur, Chiba-Falek, Ornit, Attix, Deborah K., Need, Anna C., Cirulli, Elizabeth Trilby, Voineskos, Aristotle N., Stefanis, Nikos C., Avramopoulos, Dimitrios A., Hatzimanolis, Alex, Arking, Dan E., Smyrnis, Nikolaos, Bilder, Robert Martin, Freimer, Nelson A., Cannon, Tyrone D., London, Edyth, Poldrack, Russell Alan, Sabb, Fred W., Congdon, Eliza L., Conley, Emily Drabant, Scult, Matthew A., Dickinson, Dwight, Straub, Richard E., Donohoe, Gary J., Morris, Derek W., Corvin, Aiden, Gill, Michael, Hariri, Ahmad, Weinberger, Daniel R., Pendleton, Neil, Bitsios, Panos, Rujescu, Dan, Lahti, Jari, Le Hellard, Stephanie, Keller, Matthew C., Andreassen, Ole Andreas, Deary, Ian John, Glahn, David C., Malhotra, Anil K., Lencz, Todd |
المصدر: | Molecular Psychiatry |
بيانات النشر: | Springer |
سنة النشر: | 2018 |
المجموعة: | University of Bergen: Bergen Open Research Archive (BORA-UiB) |
الوصف: | The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (~8M single-nucleotide polymorphisms (SNP) with minor allele frequency ⩾1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT). In addition, we utilized individual SNP lookups and polygenic score analyses to identify genetic overlap with other relevant neurobehavioral phenotypes. Our primary GWAS meta-analysis identified two novel SNP loci (top SNPs: rs76114856 in the CENPO gene on chromosome 2 and rs6669072 near LOC105378853 on chromosome 1) associated with cognitive performance at the genome-wide significance level (P<5 × 10^−8). Gene-based analysis identified an additional three Bonferroni-corrected significant loci at chromosomes 17q21.31, 17p13.1 and 1p13.3. Altogether, common variation across the genome resulted in a conservatively estimated SNP heritability of 21.5% (s.e.=0.01%) for general cognitive function. Integration with prior GWAS of cognitive performance and educational attainment yielded several additional significant loci. Finally, we found robust polygenic correlations between cognitive performance and educational attainment, several psychiatric disorders, birth length/weight and smoking behavior, as well as a novel genetic association to the personality trait of openness. These data provide new insight into the genetics of neurocognitive function with relevance to understanding the pathophysiology of neuropsychiatric illness. ; publishedVersion |
نوع الوثيقة: | article in journal/newspaper |
وصف الملف: | application/pdf |
اللغة: | English |
تدمد: | 1476-5578 1359-4184 |
العلاقة: | urn:issn:1476-5578; urn:issn:1359-4184; https://hdl.handle.net/1956/19271Test; https://doi.org/10.1038/mp.2016.244Test; cristin:1468236 |
DOI: | 10.1038/mp.2016.244 |
الإتاحة: | https://doi.org/10.1038/mp.2016.244Test https://hdl.handle.net/1956/19271Test |
حقوق: | Attribution CC BY ; http://creativecommons.org/licenses/by/4.0Test/ ; Copyright 2017 The Authors |
رقم الانضمام: | edsbas.BEFF4DFD |
قاعدة البيانات: | BASE |
تدمد: | 14765578 13594184 |
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DOI: | 10.1038/mp.2016.244 |