التفاصيل البيبلوغرافية
| العنوان: |
Data_Sheet_1_Are the Follicular Fluid Characteristics of Recovered Coronavirus Disease 2019 Patients Different From Those of Vaccinated Women Approaching in vitro Fertilization?.PDF |
| المؤلفون: |
Maria A. Castiglione Morelli, Assunta Iuliano, Sergio C. A. Schettini, Angela Ferri, Paola Colucci, Licia Viggiani, Ilenia Matera, Angela Ostuni |
| سنة النشر: |
2022 |
| المجموعة: |
Frontiers: Figshare |
| مصطلحات موضوعية: |
Physiology, Exercise Physiology, Nutritional Physiology, Reproduction, Cell Physiology, Systems Physiology, Animal Physiology - Biophysics, Animal Physiology - Cell, Animal Physiology - Systems, Comparative Physiology, Physiology not elsewhere classified, SARS-CoV-2, COVID-19, follicular fluid, metabolomics, NMR, anti SARS-CoV-2 immunoglobulins, proinflammatory markers |
| الوصف: |
The aim of this pilot study is to evaluate if SARS-CoV-2 infection or vaccination against SARS-CoV-2 infection induce observable metabolic effects in follicular fluid of women who are following in vitro fertilization (IVF) treatments. The possible impact of coronavirus disease 2019 (COVID-19) on fertility and IVF outcome is considered. We have selected for this study: six women vaccinated against SARS-CoV-2 infection, five recovered COVID-19 patients, and we used nine healthy women as the control group. At the time of oocytes retrieval from participants in the study, follicular fluids were collected and metabolomic analysis was performed by 1 H NMR spectroscopy in combination with multivariate analysis to interpret the spectral data. The search for antibody positivity in the follicular fluid aspirates was also carried out, together with the western blotting analysis of some inflammatory proteins, interleukin-6, tumor necrosis factor α (TNFα), and the free radical scavenger superoxide dismutase 2. Higher levels of Ala and Pro together with lower levels of lipids and trimethylamine N-oxide (TMAO) were found in follicular fluids (FFs) of vaccinated women while lower levels of many metabolites were detected in FFs of recovered COVID patients. Expression level of TNF-α was significantly lower both in recovered COVID-19 patients and vaccinated women in comparison to healthy controls. |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/dataset/Data_Sheet_1_Are_the_Follicular_Fluid_Characteristics_of_Recovered_Coronavirus_Disease_2019_Patients_Different_From_Those_of_Vaccinated_Women_Approaching_in_vitro_Fertilization_PDF/19214682Test |
| DOI: |
10.3389/fphys.2022.840109.s001 |
| الإتاحة: |
https://doi.org/10.3389/fphys.2022.840109.s001Test
https://figshare.com/articles/dataset/Data_Sheet_1_Are_the_Follicular_Fluid_Characteristics_of_Recovered_Coronavirus_Disease_2019_Patients_Different_From_Those_of_Vaccinated_Women_Approaching_in_vitro_Fertilization_PDF/19214682Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.BEB2D03D |
| قاعدة البيانات: |
BASE |
