دورية أكاديمية
Use of a DNAemia cut-off for monitoring human cytomegalovirus infection reduces the number of preemptively treated children and young adults receiving hematopoietic stem-cell transplantation compared with qualitative pp65 antigenemia
| العنوان: | Use of a DNAemia cut-off for monitoring human cytomegalovirus infection reduces the number of preemptively treated children and young adults receiving hematopoietic stem-cell transplantation compared with qualitative pp65 antigenemia |
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| المؤلفون: | Lilleri D., Gerna G., Furione M., Bernardo M. E., Giorgiani G., Telli S., Baldanti F., Locatelli F. |
| المساهمون: | Lilleri, D., Gerna, G., Furione, M., Bernardo, M. E., Giorgiani, G., Telli, S., Baldanti, F., Locatelli, F. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adolescent, Adult, Antigens, Viral, Child, Preschool, Cytomegalovirus, Cytomegalovirus Infections, DNA, Female, Follow-Up Studies, Humans, Infant, Newborn, Male, Hematopoietic Stem Cell Transplantation |
| الوصف: | We performed a randomized trial comparing the use of quantitative DNAemia versus positive antigenemia for starting preemptive antihuman cytomegalovirus (HCMV) therapy in hematopoietic stem-cell transplantation (HSCT) recipients. In the DNAemia arm, antiviral therapy was initiated on reaching a DNAemia cut-off of 10 000 DNA copies/mL of whole blood, whereas in the antigenemia arm, therapy was started in the presence of a positive antigenemia. The aim of the study was to compare the number of patients treated in the 2 arms. On the whole, 178 patients (89 in each arm), receiving unmanipulated HSCT from either a relative or an unrelated donor, completed the study. Although the incidence of HCMV infection was comparable in DNAemia and antigenemia arms (34% vs 42%, respectively, P = .259), the number of patients treated was significantly lower in the DNAemia arm (18% vs 31%, P = .026). No patient developed HCMV disease. The use of a DNAemia cut-off avoids unnecessary antiviral treatment. © 2007 by The American Society of Hematology. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000249800900079; volume:110; issue:7; firstpage:2757; lastpage:2760; numberofpages:4; journal:BLOOD; http://hdl.handle.net/20.500.11768/106172Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-34948871563 |
| DOI: | 10.1182/blood-2007-03-080820 |
| الإتاحة: | https://doi.org/20.500.11768/106172Test https://doi.org/10.1182/blood-2007-03-080820Test https://hdl.handle.net/20.500.11768/106172Test |
| رقم الانضمام: | edsbas.BE4CDE31 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1182/blood-2007-03-080820 |
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