دورية أكاديمية

Use of thyroid hormones in hypothyroid and euthyroid patients:A survey of members of the Endocrine Society of Australia

التفاصيل البيبلوغرافية
العنوان: Use of thyroid hormones in hypothyroid and euthyroid patients:A survey of members of the Endocrine Society of Australia
المؤلفون: Lafontaine, Nicole, Brown, Suzanne J., Perros, Petros, Papini, Enrico, Nagy, Endre V., Attanasio, Roberto, Hegedüs, Laszlo, Walsh, John P.
المصدر: Lafontaine , N , Brown , S J , Perros , P , Papini , E , Nagy , E V , Attanasio , R , Hegedüs , L & Walsh , J P 2024 , ' Use of thyroid hormones in hypothyroid and euthyroid patients : A survey of members of the Endocrine Society of Australia ' , Clinical Endocrinology , vol. 100 , no. 5 , pp. 477-485 . https://doi.org/10.1111/cen.15049Test
سنة النشر: 2024
المجموعة: University of Southern Denmark: Research Output / Syddansk Universitet
مصطلحات موضوعية: Australia, endocrinologist, hypothyroidism, thyroxine, triiodothyronine, Humans, Thyroid Hormones/therapeutic use, Pregnancy, Thyrotropin/therapeutic use, Female, Hypothyroidism/drug therapy, Surveys and Questionnaires, Triiodothyronine/therapeutic use, Thyroxine/therapeutic use
الوصف: Objective: Hypothyroidism is a common endocrine condition usually managed with levothyroxine (LT4). However, controversy remains around the use of liothyronine (LT3). We aimed to investigate the practices of Australian endocrinologists when managing patients with hypothyroidism, their use of LT3 + LT4 combination therapy and use of thyroid hormones in euthyroid patients. Design and Participants: Members of the Endocrine Society of Australia (ESA) were invited to participate in an online questionnaire. Measurements: We analysed questionnaires that had complete demographic data. Results: Eighty-seven questionnaires fulfilled the criteria. LT4 was used as first line treatment for hypothyroidism by all respondents. Only 45% reported that their patients were dispensed the brand of LT4 that they recommend. LT3 (alone or in combination) was prescribed by 44% in their clinical practice. Although 49% of respondents would consider LT3 + LT4 in patients with normal TSH who had ongoing symptoms of hypothyroidism, the inability of LT4 to restore normal physiology was ranked the least likely explanation for persistent symptoms and only 32% would consider it for themselves if they were diagnosed with hypothyroidism. The majority (55%), in accordance with evidence, would not prescribe thyroid hormone to euthyroid individuals but 39% would consider use in euthyroid female infertility with high levels of thyroid antibodies and 11% in euthyroid patients with a simple goitre growing over time. LT4 use in pregnancy was variable among members. Conclusions: Australian endocrinologists mostly follow international guidelines when prescribing thyroid hormone therapy and many prescribe combination LT3 and LT4 therapy, particularly for patients who remain symptomatic on LT4 monotherapy. Prescribing practices are largely similar to other countries who have completed similar questionnaires.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
العلاقة: https://portal.findresearcher.sdu.dk/da/publications/a0c72cd0-1115-4d1b-a44e-0161e3c9e608Test
DOI: 10.1111/cen.15049
الإتاحة: https://doi.org/10.1111/cen.15049Test
https://portal.findresearcher.sdu.dk/da/publications/a0c72cd0-1115-4d1b-a44e-0161e3c9e608Test
https://findresearcher.sdu.dk/ws/files/259207847/Clinical_Endocrinology_-_2024_-_Lafontaine_-_Use_of_thyroid_hormones_in_hypothyroid_and_euthyroid_patients_A_survey_of.pdfTest
حقوق: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.BE3CE49E
قاعدة البيانات: BASE