دورية أكاديمية
Dopamine Modulates Serotonin Innervation in the Drosophila Brain
| العنوان: | Dopamine Modulates Serotonin Innervation in the Drosophila Brain |
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| المؤلفون: | Niens, Janna, Reh, Fabienne, Çoban, Büşra, Cichewicz, Karol, Eckardt, Julia, Liu, Yi-Ting, Hirsh, Jay, Riemensperger, Thomas D. |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2017 |
| المجموعة: | Georg-August-Universität Göttingen: GoeScholar |
| الوقت: | 570 |
| الوصف: | Parkinson’s disease (PD) results from a progressive degeneration of the dopaminergic nigrostriatal system leading to a decline in movement control, with resting tremor, rigidity and postural instability. Several aspects of PD can be modeled in the fruit fly, Drosophila melanogaster, including a-synuclein-induced degeneration of dopaminergic neurons, or dopamine (DA) loss by genetic elimination of neural DA synthesis. Defective behaviors in this latter model can be ameliorated by feeding the DA precursor L-DOPA, analogous to the treatment paradigm for PD. Secondary complication from L-DOPA treatment in PD patients are associated with ectopic synthesis of DA in serotonin (5-HT)-releasing neurons, leading to DA/5-HT imbalance. Here we examined the neuroanatomical adaptations resulting from imbalanced DA/5-HT signaling in Drosophila mutants lacking neural DA. We find that, similar to rodent models of PD, lack of DA leads to increased 5-HT levels and arborizations in specific brain regions. Conversely, increased DA levels by L-DOPA feeding leads to reduced connectivity of 5-HT neurons to their target neurons in the mushroom body (MB). The observed alterations of 5-HT neuron plasticity indicate that loss of DA signaling is not solely responsible for the behavioral disorders observed in Drosophila models of PD, but rather a combination of the latter with alterations of 5-HT circuitry. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1663-4365 1662-5137 |
| العلاقة: | https://resolver.sub.uni-goettingen.de/purl?gro-2/59024Test; https://resolver.sub.uni-goettingen.de/purl?gs-1/14799Test |
| DOI: | 10.3389/fnsys.2017.00076 |
| الإتاحة: | https://doi.org/10.3389/fnsys.2017.00076Test https://resolver.sub.uni-goettingen.de/purl?gro-2/59024Test https://resolver.sub.uni-goettingen.de/purl?gs-1/14799Test |
| حقوق: | CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.BE389331 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16634365 16625137 |
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| DOI: | 10.3389/fnsys.2017.00076 |