دورية أكاديمية
Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens
| العنوان: | Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens |
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| المؤلفون: | Vollenweider, Vera, Rehm, Karoline, Chepkirui, Clara, Pérez-Berlanga, Manuela, Polymenidou, Magdalini, Piel, Jörn, Bigler, Laurent, Kümmerli, Rolf |
| المصدر: | Vollenweider, Vera; Rehm, Karoline; Chepkirui, Clara; Pérez-Berlanga, Manuela; Polymenidou, Magdalini; Piel, Jörn; Bigler, Laurent; Kümmerli, Rolf (2024). Antimicrobial activity of iron-depriving pyoverdines against human opportunistic pathogens. eLife, 13:RP92493. |
| بيانات النشر: | eLife Sciences Publications Ltd. |
| سنة النشر: | 2024 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Department of Chemistry, Department of Quantitative Biomedicine, 540 Chemistry |
| الوصف: | The global rise of antibiotic resistance calls for new drugs against bacterial pathogens. A common approach is to search for natural compounds deployed by microbes to inhibit competitors. Here we show that the iron chelating pyoverdines, siderophores produced by environmental Pseudomonas spp., have strong antibacterial properties by inducing iron starvation and growth arrest in pathogens. A screen of 320 natural Pseudomonas isolates used against 12 human pathogens uncovered several pyoverdines with particularly high antibacterial properties and distinct chemical characteristics. The most potent pyoverdine effectively reduced growth of the pathogens Acinetobacter baumannii, Klebsiella pneumoniae and Staphylococcus aureus in a concentration- and iron-dependent manner. Pyoverdine increased survival of infected Galleria mellonella host larvae, and showed low toxicity for the host, mammalian cell lines, and erythrocytes. Furthermore, experimental evolution combined with whole-genome sequencing revealed reduced potentials for resistance evolution compared to an antibiotic. Thus, pyoverdines from environmental strains could become new sustainable antibacterials against human pathogens. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2050-084X |
| العلاقة: | https://www.zora.uzh.ch/id/eprint/255328/1/Vollenweider_eLife_2024.pdfTest; urn:issn:2050-084X |
| DOI: | 10.5167/uzh-255328 |
| DOI: | 10.7554/elife.92493.1 |
| الإتاحة: | https://doi.org/10.5167/uzh-255328Test https://doi.org/10.7554/elife.92493.1Test https://www.zora.uzh.ch/id/eprint/255328Test/ https://www.zora.uzh.ch/id/eprint/255328/1/Vollenweider_eLife_2024.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess ; Creative Commons: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) ; http://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: | edsbas.BDD8ED11 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.5167/uzh-255328 |