دورية أكاديمية
Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development
| العنوان: | Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development |
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| المؤلفون: | Mani, Sachin, Toapanta, Franklin, Mcarthur, Monica, Qadri, Firdausi, Svennerholm, Ann-Mari, Devriendt, Bert, Phalipon, Armelle, Cohen, Daniel, Sztein, Marcelo |
| المساهمون: | PATH Seattle, University of Maryland School of Medicine, University of Maryland System, International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), Göteborgs Universitet = University of Gothenburg (GU), Universiteit Gent = Ghent University (UGENT), Pathogénie microbienne moléculaire, Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sackler Faculty of Medicine, Tel Aviv University (TAU), Research outlined in this manuscript were supported in part by the following grants - grants R01-AI036525, U19-AI082655 (Cooperative Center for Human Immunology CCHI ) and U19-AI109776 (Center of Excellence for Translational Research CETR from the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health (NIH), grant GR01263 through PATH Enteric Vaccine Inititative (EVI), with additional support from the Bill and Melinda Gates Foundation and the Swedish Research Council, and grant 261472 “STOPENTERICS” from the European Union Seventh Framework Programme. In addition, B. Devriendt was supported by a postdoctoral grant from Fonds voor Wetenschappelijk Onderzoek – Vlaanderen FWO, Research Foundation, Flanders . The manuscript content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health or any other granting/funding organizations or agencies., European Project: 261472,EC:FP7:HEALTH,FP7-HEALTH-2010-single-stage,STOPENTERICS(2010) |
| المصدر: | ISSN: 0264-410X. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2019 |
| المجموعة: | Institut Pasteur: HAL |
| مصطلحات موضوعية: | B cells, Correlates of protection (CoP), Enterotoxigenic Escherichia coli (ETEC), IgA, IgG, Immunocorrelate, Mucosal antibodies, Shigella, T cells, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology |
| الوصف: | International audience ; The generation of robust systemic and mucosal antibody and cell-mediated immune (CMI) responses that are protective, long-lasting, and can quickly be recalled upon subsequent re-exposure to the cognate antigen is the key to the development of effective vaccine candidates. These responses, whether they represent mechanistic or non-mechanistic immunological correlates of protection, usually entail the activation of T cell memory and effector subsets (T-CMI) and induction of long-lasting memory B cells. However, for ETEC and Shigella, the precise role of these key immune cells in primary and secondary (anamnestic) immune responses remains ill-defined. A workshop to address immune correlates for ETEC and Shigella, in general, and to elucidate the mechanistic role of T-cell subsets and B-cells, both systemically and in the mucosal microenvironment, in the development of durable protective immunity against ETEC and Shigella was held at the recent 2nd Vaccines against Shigella and ETEC (VASE) conference in June 2018. This report is a summary of the presentations and the discussion that ensued at the workshop. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31230883; info:eu-repo/grantAgreement/EC/FP7/261472/EU/Vaccination against Shigella and ETEC: novel antigens, novel approaches/STOPENTERICS; pasteur-02874931; https://pasteur.hal.science/pasteur-02874931Test; https://pasteur.hal.science/pasteur-02874931/documentTest; https://pasteur.hal.science/pasteur-02874931/file/1-s2.0-S0264410X1930372X-main.pdfTest; PUBMED: 31230883 |
| DOI: | 10.1016/j.vaccine.2019.03.040 |
| الإتاحة: | https://doi.org/10.1016/j.vaccine.2019.03.040Test https://pasteur.hal.science/pasteur-02874931Test https://pasteur.hal.science/pasteur-02874931/documentTest https://pasteur.hal.science/pasteur-02874931/file/1-s2.0-S0264410X1930372X-main.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.BD6FC1EB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.vaccine.2019.03.040 |
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