دورية أكاديمية
The ESCRT machinery: remodeling, repairing, and sealing membranes
| العنوان: | The ESCRT machinery: remodeling, repairing, and sealing membranes |
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| المؤلفون: | Olmos Buchelt, Yolanda |
| بيانات النشر: | MDPI |
| سنة النشر: | 2022 |
| المجموعة: | Universidad Complutense de Madrid (UCM): E-Prints Complutense |
| مصطلحات موضوعية: | 576.3, 577.2, ESCRT, Membrane scission, Reverse topology, Nuclear envelope, Lysosome, Membrane sealing, Membrane repair, Biología celular (Biología), Biología molecular (Biología), 2407 Biología Celular, 2415 Biología Molecular |
| الوصف: | The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that is used by the cell to perform reverse membrane scission in essential processes like protein degradation, cell division, and release of enveloped retroviruses. ESCRT-III, together with the AAA ATPase VPS4, harbors the main remodeling and scission function of the ESCRT machinery, whereas earlyacting ESCRTs mainly contribute to protein sorting and ESCRT-III recruitment through association with upstream targeting factors. Here, we review recent advances in our understanding of the molecular mechanisms that underlie membrane constriction and scission by ESCRT-III and describe the involvement of this machinery in the sealing and repairing of damaged cellular membranes, a key function to preserve cellular viability and organellar function. ; Depto. de Biología Celular ; Fac. de Ciencias Biológicas ; TRUE ; Ministerio de Ciencia e Innovación (MICINN)/FEDER ; pub |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | PGC2018-094164-A-I00; RYC-2017-22539; Electronic: 2077-0375; https://doi.org/10.3390/membranes12060633Test; https://www.mdpi.com/2077-0375/12/6/633Test; https://hdl.handle.net/20.500.14352/72486Test |
| DOI: | 10.3390/membranes12060633 |
| الإتاحة: | https://doi.org/20.500.14352/72486Test https://doi.org/10.3390/membranes12060633Test https://hdl.handle.net/20.500.14352/72486Test https://www.mdpi.com/2077-0375/12/6/633Test |
| حقوق: | Atribución 3.0 España ; open access ; https://creativecommons.org/licenses/by/3.0/esTest/ |
| رقم الانضمام: | edsbas.BD6C13D9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/membranes12060633 |
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