دورية أكاديمية
Cells of the adult human heart
| العنوان: | Cells of the adult human heart |
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| المؤلفون: | Litviňuková, M., Talavera-López, C., Maatz, H., Reichart, D., Worth, C.L., Lindberg, E.L., Kanda, M., Polanski, K., Heinig, M., Lee, M.l, Nadelmann, E.R., Roberts, K., Tuck, L., Fasouli, E.S., DeLaughter, D.M., McDonough, B., Wakimoto, H., Gorham, J.M., Samari, S., Mahbubani, K.T., Saeb-Parsy, K., Patone, G., Boyle, J.J., Zhang, H., Viveiros, A., Oudit, G.Y., Bayraktar, O., Seidman, J.G., Seidman, C.E., Noseda, M., Hubner, N., Teichmann, S.A. |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2020 |
| المجموعة: | Max-Delbrueck-Center for Molecular Medicine, Berlin: MDC Repository |
| مصطلحات موضوعية: | Cardiovascular and Metabolic Diseases |
| الوصف: | Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require deeper understanding of the healthy heart's molecular processes. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavor. Here, using state-of-the-art analyses of large-scale single-cell and nuclei transcriptomes, we characterise six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes, and fibroblasts, revealing distinct atrial and ventricular subsets with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment we identify cardiac resident macrophages with inflammatory and protective transcriptional signatures. Further, inference of cell-cell interactions highlight different macrophage-fibroblast-cardiomyocyte networks between atria and ventricles that are distinct from skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a healthy reference for future studies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; other |
| اللغة: | English |
| العلاقة: | http://edoc.mdc-berlin.de/19407/1/19407oa.pdfTest; http://edoc.mdc-berlin.de/19407/7/19407suppl.zipTest; Cells of the adult human heart. Litviňuková, M. and Talavera-López, C. and Maatz, H. and Reichart, D. and Worth, C.L. and Lindberg, E.L. and Kanda, M. and Polanski, K. and Heinig, M. and Lee, M.l and Nadelmann, E.R. and Roberts, K. and Tuck, L. and Fasouli, E.S. and DeLaughter, D.M. and McDonough, B. and Wakimoto, H. and Gorham, J.M. and Samari, S. and Mahbubani, K.T. and Saeb-Parsy, K. and Patone, G. and Boyle, J.J. and Zhang, H. and Zhang, H. and Viveiros, A. and Oudit, G.Y. and Bayraktar, O. and Seidman, J.G. and Seidman, C.E. and Noseda, M. and Hubner, N. and Teichmann, S.A. Nature 588 (7838): 466-472. 17 December 2020 |
| DOI: | 10.1038/s41586-020-2797-4 |
| الإتاحة: | https://doi.org/10.1038/s41586-020-2797-4Test http://edoc.mdc-berlin.de/19407Test/ https://edoc.mdc-berlin.de/19407Test/ http://edoc.mdc-berlin.de/19407/1/19407oa.pdfTest http://edoc.mdc-berlin.de/19407/7/19407suppl.zipTest |
| حقوق: | cc_by_4 |
| رقم الانضمام: | edsbas.BD24EB23 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41586-020-2797-4 |
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